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Adenovirus Transcription

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Part of the book series: The Viruses ((VIRS))

Abstract

The emphasis in this chapter is on the regulation and kinetics of adenovirus transcription. Recent references have been selected to provide readers with starting points to explore the background literature. A more complete treatment of earlier work on the subject can be found in Tooze (1980). Two excellent recent reviews on the topic are Flint (1982) and Ziff (1980).

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References

  • Akusjärvi, G., and Persson, H., 1980, Controls of RNA splicing and termination in the major late adenovirus transcription unit, Nature (London) 292:420.

    Article  Google Scholar 

  • Akusjärvi, G., and Persson, H., 1981, Gene and mRNA for precursor polypeptide VI from adenovirus type 2, J. Virol. 38:469.

    PubMed  Google Scholar 

  • Akusjärvi, G., and Pettersson, U., 1979, Sequence analysis of adenovirus DNA: Complete nucleotide sequence of the spliced 5′ noncoding region of adenovirus 2 hexon messenger RNA, Cell 16:841.

    Article  PubMed  Google Scholar 

  • Akusjärvi, G., Mathews, M.B., Anderson, P., Vennstrom, B., and Pettersson, U., 1980, Struc ture of genes for virus-associated RNAI and RNAII of adenovirus type 3, Proc. Natl. Acad. Sci. U.S.A. 77:2424.

    Article  PubMed  Google Scholar 

  • Avvedimento, V.E., Vogeli, G., Yamada, Y., Maizel, J.V., Jr., Pastan, I., and de Crombrugghe, B., 1980, Correlation between splicing sites within an intron and their sequence complementarity with U1 RNA, Cell 21:689.

    Article  PubMed  CAS  Google Scholar 

  • Babich, A., and Nevins, J.R., 1981, The stability of early adenovirus mRNA is controlled by the viral 72 kd DNA-binding protein, Cell 26:371.

    Article  PubMed  CAS  Google Scholar 

  • Bachenheimer, S., and Darnell, J.E., 1975, Adenovirus-2 mRNA is transcribed as part of a high-molecular-weight precursor RNA, Proc. Natl. Acad. Sci. U.S.A. 72:4445.

    Article  PubMed  CAS  Google Scholar 

  • Baker, C.C., and Ziff, E.B., 1981, Promoters and heterogeneous 5′ termini of the messenger RNA’s of adenovirus serotype 2, J. Mol. Biol. 149:189.

    Article  PubMed  CAS  Google Scholar 

  • Benoist, C., and Chambon, P., 1981, In vivo sequence requirements of the SV40 early promoter region, Nature (London) 290:304.

    Article  CAS  Google Scholar 

  • Berget, S.M., and Sharp, P.A., 1979, Structure of late adenovirus 2 heterogeneous nuclear RNA, J. Mol. Biol. 129:547.

    Article  PubMed  CAS  Google Scholar 

  • Berget, S.M., Moore, C., and Sharp, P.A., 1977, Spliced segments at the 5′ terminus of adenovirus 2 late mRNA, Proc. Natl. Acad. Sci. U.S.A. 74:3171.

    Article  PubMed  CAS  Google Scholar 

  • Berk, A.J., and Sharp, P.A., 1978, Structure of adenovirus 2 early mRNAs, Cell 14:695.

    Article  PubMed  CAS  Google Scholar 

  • Berk, A.J., Lee, F., Harrison, T., Williams, J., and Sharp, P.A., 1979, Pre-early adenovirus 5 gene products regulate transcription and processing of early viral messenger RNAs, Cell 17:935.

    Article  PubMed  CAS  Google Scholar 

  • Bertrand, K., Korn, L., Lee, F., Platt, T., Squires, C.L., Squires, C., and Yanofsky, C., 1975, New features of the regulation of the tryptophan operon, Science 189:22.

    Article  PubMed  CAS  Google Scholar 

  • Beyer, A.L., Bouton, A.H., Hodge, L.D., and Miller, O.L., Jr., 1981, Visualization of the major late R strand transcription unit of adenovirus serotype 2, J. Mol. Biol. 147:269–295.

    Article  PubMed  CAS  Google Scholar 

  • Blanchard, J.M., Weber, J., Jelinek, W., and Darnell, J.E., 1978, In vitro RNA-RNA splicing in adenovirus 2 mRNA formation, Proc. Natl. Acad. Sci. U.S.A. 75:5344.

    Article  PubMed  CAS  Google Scholar 

  • Blanton, R.A., and Carter, T.H., 1979, Autoregulation of adenovirus type 5 early gene expression. III. Transcription studies in isolated nuclei, J. Virol. 29:458.

    PubMed  CAS  Google Scholar 

  • Bos, J.L., Polder, L.J., Bernards, R., Schrier, P.I., van der Elsen, P.J., van der Eb, A.J., and van Ormondt, H., 1981, The 2.2 kb Elb mRNA of human Adl2 and Ad5 codes for two tumor antigens starting at different AUG triplets, Cell 27:121.

    Article  PubMed  CAS  Google Scholar 

  • Breathnach, R., Benoist, C., O’Hare, K., Gannon, F., and Chambon, P., 1978, Ovalbumin gene: Evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries, Proc. Natl. Acad. Sci. U.S.A. 75:4853.

    Article  PubMed  CAS  Google Scholar 

  • Chen-Kiang, S., Nevins, J.R., and Darnell, J.E., Jr., 1979, N-6 methyl-adenosine in adenovirus type 2 nuclear RNA is conserved in the formation of messenger RNA, J. Mol. Biol. 135:733.

    Article  PubMed  CAS  Google Scholar 

  • Chen-Kiang, S., Wolgemuth, D.J., Hsu, M.T., and Darnell, J.E., 1982, Transcription and accurate polyadenylation in vitro of RNA from the major late adenovirus 2 transcription unit, Cell 28:575.

    Article  PubMed  CAS  Google Scholar 

  • Chow, L., Gelinas, R., Broker, T., and Roberts, R., 1977, An amazing sequence arrangement at the 5′ ends of adenovirus 2 messenger RNA, Cell 12:1.

    Article  PubMed  CAS  Google Scholar 

  • Chow, L.T., Broker, T.R., and Lewis, J.B., 1979, Complex splicing patterns of RNAs from the early regions of adenovirus-2, J. Mol. Biol. 134:265.

    Article  PubMed  CAS  Google Scholar 

  • Chow, L.T., Lewis, J.B., and Broker, T.R., 1980, RNA transcription and splicing at early and intermediate times after adenovirus-2 infection, Cold Spring Harbor Symp. Quant. Biol. 44:401.

    Article  PubMed  CAS  Google Scholar 

  • Corden, J., Wasylyk, B., Buchwalder, A., Sassone-Corsi, P., Kedinger, C., and Chambon, P., 1980, Promoter sequences of eukaryotic protein-coding genes, Science 209:1406.

    Article  PubMed  CAS  Google Scholar 

  • Craig, E.A., and Raskas, H.J., 1974, Effect of cycloheximide on RNA metabolism early in productive infection with adenovirus 2, J. Virol. 14:26.

    PubMed  CAS  Google Scholar 

  • Daniell, E., Groff, D.E., and Fedor, M.J., 1981, Adenovirus chromatin structure at different stages of infection, Mol. Cell. Biol. 1:1094.

    PubMed  CAS  Google Scholar 

  • Davis, B.D., Dulbecco, R., Eisen, H.N., and Ginsberg, H.S., 1980, Microbiology, 3rd ed., Chapter 54, Harper & Row, New York.

    Google Scholar 

  • Eggerding, F., and Raskas, H.J., 1978, Effect of protein synthesis inhibitors on viral mRNA’s synthesized early in adenovirus type 2 infection, J. Virol. 25:453.

    PubMed  CAS  Google Scholar 

  • Ensinger, M.J., and Ginsberg, H.S., 1972, Selective and preliminary characterization of temperature-sensitive mutants of type 5 adenovirus, J. Virol. 10:328.

    PubMed  CAS  Google Scholar 

  • Evans, R., Weber, J., Ziff, E., and Darnell, J.E., 1979, Premature termination during adenovirus transcription, Nature (London) 278:367.

    Article  CAS  Google Scholar 

  • Falvey, E., and Ziff, E., 1983, Sequence arrangement and protein coding capacity of the adenovirus type 2 i leader, J. Virol. 45:185–191.

    PubMed  CAS  Google Scholar 

  • Fire, A., Baker, C.C., Manley, J.L., Ziff, E.B., and Sharp, P.A., 1981, In vitro transcription of adenovirus, J. Virol. 40:703.

    PubMed  CAS  Google Scholar 

  • Fitzgerald, M., and Shenk, T., 1981, The sequence 5′-AAUAAA-3′ forms part of the recognition site for polyadenylation of late SV40 mRNAs, Cell 24:251.

    Article  PubMed  CAS  Google Scholar 

  • Flint, S.J., 1982, Expression of adenoviral genetic information in productively infected cells, B.B.A. Reviews on Cancer 651:175–208.

    CAS  Google Scholar 

  • Flint, S.J., and Sharp, P.A., 1976, Adenovirus transcription. V. Quantitation of viral RNA sequences in adenovirus 2 infected and transformed cells, J. Mol. Biol. 106:749.

    Article  PubMed  CAS  Google Scholar 

  • Fowlkes, D.M., and Shenk, T., 1980, Transcription control regions of the adenovirus VAI RNA gene, Cell 22:405.

    Article  PubMed  CAS  Google Scholar 

  • Fraser, N.W., and Ziff, E., 1978, Adenovirus-2 late messenger RNAs: Mapping and comparison structure near poly(A), J. Mol. Biol. 124:27.

    Article  PubMed  CAS  Google Scholar 

  • Fraser, N.W., Nevins, J.R., Ziff, E., and Darnell, J.E., 1979a, The major late adenovirus type-2 transcription unit: Termination is downstream from the last poly(A) site, J. Mol. Biol. 129:643.

    Article  CAS  Google Scholar 

  • Fraser, N.W., Sehgal, P., and Darnell, J.E., 1979b, Multiple discrete sites for premature RNA chain termination late in adenovirus-2 infection: Enhancement by 5,6-dichloro-l-β-D-ribofuranosylbenzimidazole, Proc. Natl. Acad. Sci. U.S.A. 76:2571.

    Article  CAS  Google Scholar 

  • Fraser, N.W., Baker, C.C., Moore, M.A., and Ziff, E.B., 1982, Poly(A) sites of adenovirus serotype 2 transcription units, J. Mol. Biol. 155:207.

    Article  PubMed  CAS  Google Scholar 

  • Gaynor, R., Tsukamoto, A., Montell, C., and Berk, A.J., 1982, Enhanced expression of adenovirus transforming proteins, J. Virol. 44:276–285.

    PubMed  CAS  Google Scholar 

  • Gelinas, R.E., and Roberts, R., 1977, One predominant 5′-undecanucleotide in adenovirus 2 late messenger RNAs, Cell 11:533.

    Article  PubMed  CAS  Google Scholar 

  • Gluzman, Y., Sambrook, J., and Frisque, R.J., 1980, Expression of early genes of origin-defective mutants of simian virus 40, Proc. Natl. Acad. Sci. U.S.A. 77:1432.

    Article  Google Scholar 

  • Goldberg, M.L., 1979, Sequence analysis of Drosophila histone genes, Ph.D. thesis, Stanford University.

    Google Scholar 

  • Goldenberg, C.J., and Raskas, H.J., 1979, Splicing patterns of nuclear precursors to the mRNA for adenovirus 2 DNA binding protein, Cell 16:131.

    Article  PubMed  CAS  Google Scholar 

  • Goldenberg, C.J., and Raskas, H.J., 1980, In vitro processing of intervening sequences in the precursors of messenger ribonucleic acid for adenovirus 2 deoxyribonucleic acid binding protein, Biochemistry 19:2719.

    Article  PubMed  CAS  Google Scholar 

  • Grosschedl, R., and Birnstiel, M.L., 1980, Identification of regulatory sequences in the prelude sequences of an H2A histon gene by the study of specific deletion mutants in vivo, Proc. Natl. Acad. Sci. U.S.A. 77:1432.

    Article  PubMed  CAS  Google Scholar 

  • Harrison, T., Graham, F., and Williams, J., 1977, Host range mutants of adenovirus type 5 defective for growth in HeLa cells, Virology 77:319.

    Article  PubMed  CAS  Google Scholar 

  • Horwitz, M.S., Scharff, M.D., and Maizel, J.V., Jr., 1969, Synthesis and assembly of adenovirus 2. I. Polypeptide synthesis, assembly of capsomers and morphogenesis of the virion, Virology 39:682.

    Article  PubMed  CAS  Google Scholar 

  • Houweling, A., Elsen, P.J., and van der Eb, A.J., 1980, Partial transformation of primary rat cells by the left most 4.5% fragment of adenovirus 5 DNA, Virology 105:537–550.

    Article  PubMed  CAS  Google Scholar 

  • Hu, S., and Manley, J.L., 1981, DNA sequence required for the initiation of transcription in vitro from the major late promoter of adenovirus 2, Proc. Natl. Acad. Sci. U.S.A. 78:820.

    Article  PubMed  CAS  Google Scholar 

  • Jones, N., and Shenk, T., 1979a, Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cells, Cell 17:783.

    Article  Google Scholar 

  • Jones, N., and Shenk, T., 1979b, An adenovirus type 5 early gene function regulates expression of other early viral genes, Proc. Natl. Acad. Sci. U.S.A. 76:3665.

    Article  PubMed  CAS  Google Scholar 

  • Kedinger, C., Brison, O., Perrin, F., and Wilhelm, J., 1978, Structural analysis of viral replication intermediates isolated from adenovirus type 2-infected HeLa cell nuclei, J. Virol. 26:364.

    PubMed  CAS  Google Scholar 

  • Keohavong, P., Gattoni, R., LeMoullec, J.M., Jacob, M., and Stevenin, J., 1982, The orderly splicing of the first three leaders of the adenovirus-2 major late transcripts, Nucleic Acids Res. 10:1215.

    Article  PubMed  CAS  Google Scholar 

  • Kitchingham, G.R., and Westphal, H., 1980, The structure of adenovirus 2 early nuclear and cytoplasmic RNAs, J. Mol. Biol. 137:23.

    Article  Google Scholar 

  • Larsen, A., and Weintraub, H., 1982, An altered DNA conformation detected by SI nuclease occurs at specific regions in active chick globin chromatin, Cell 29:609–622.

    Article  PubMed  CAS  Google Scholar 

  • Leibowitz, P., and Weissman, S.M., 1979, Organization and transcription of the simian virus 40 genome, Curr. Top. Microbiol. Immunol. 87:44.

    Google Scholar 

  • Lee, D.C., and Roeder, R.G., 1981, Transcription of adenovirus type 2 genes in a cell-free system: Apparent heterogeneity of initiation at some promoters, Mol. Cell. Biol. 1:635.

    PubMed  CAS  Google Scholar 

  • Lee, D.C., Roeder, R.G., and Wold, W.S.M., 1982, DNA sequences affecting specific initiation of transcription in vitro from the EIII promoter of adenovirus 2, Proc. Natl. Acad. Sci. U.S.A. 79:41.

    Article  PubMed  CAS  Google Scholar 

  • Lerner, M.R., Andrews, N.C., Miller, G., and Steitz, J.A., 1981a, Two small RNAs encoded by Epstein-Barr virus and complexed with protein are precipitated by antibodies from patient with systemic lupus erythematosus, Proc. Natl. Acad. Sci. U.S.A. 78:805.

    Article  PubMed  CAS  Google Scholar 

  • Lerner, M.R., Boyle, J.A., Hardin, J.A., and Steitz, J.A., 1981b, Two novel classes of small ribonucleoproteins detected by antibodies associated with lupus erythematosus, Science 211:400.

    Article  PubMed  CAS  Google Scholar 

  • Lewis, J., and Mathews, M.B., 1980, Control of adenovirus early gene expression: A class of immediate early products, Cell 21:303.

    Article  PubMed  CAS  Google Scholar 

  • Lucas, J.J., and Ginsberg, H.S., 1971, Synthesis of virus-specific RNA in KB cells infected with type 2 adenovirus, J. Virol. 8:203.

    PubMed  CAS  Google Scholar 

  • Manley, J.L., Sharp, P.A., and Gefter, M.L., 1979, RNA synthesis in isolated nuclei: Identification and comparison of Ad2 encoded transcripts synthesized in vitro and in vivo, J. Mol. Biol. 135:171.

    Article  PubMed  CAS  Google Scholar 

  • Manley, J.L., Fire, A., Cano, A., Sharp, P.A., and Gefter, M.L., 1980, RNA-dependent transcription of adenovirus genes in a soluble whole-cell extract, Proc. Natl. Acad. Sci. U.S.A. 77:3855.

    Article  PubMed  CAS  Google Scholar 

  • Manley, J.L., Sharp, P.A., and Gefter, M.L., 1982, RNA synthesis in isolated nuclei: Processing of adenovirus 2 late mRNA precursor, J. Mol. Biol. 159:581.

    Article  PubMed  CAS  Google Scholar 

  • Mathews, M.B., 1975, Genes for VA-RNA in adenovirus 2, Cell 6:223.

    Article  PubMed  CAS  Google Scholar 

  • Mathis, D.J., Elkaim, R., Kedenjer, C., Sassone-Corsi, P., and Chambon, P., 1981, Specific in vitro initiation of transcription on the adenovirus type 2 early and late EII transcription units, Proc. Natl. Acad. Sci. U.S.A. 78:7383.

    Article  PubMed  CAS  Google Scholar 

  • Meyer, J., Neuwald, P.D., Lai, S.-P., Maizel, J.V., and Westphal, H., 1977, Electron microscopy of late adenovirus type 2 mRNA hybridized to double-stranded viral DNA, J. Virol. 21:1010.

    PubMed  CAS  Google Scholar 

  • Montell, C., Fisher, E.F., Caruthers, M.H., and Berk, A.J., 1982, Resolving the functions of overlapping viral genes by site-specific mutagenesis at a mRNA splice site, Nature (London) 295:380.

    Article  CAS  Google Scholar 

  • Moss, B., and Koczot, F., 1976, Sequence of methylated nucleotides at the 5′-terminus of adenovirus-specific RNA,J. Virol. 17:385.

    PubMed  CAS  Google Scholar 

  • Nevins, J.R., 1981, Mechanism of activation of early viral transcription by the adenovirus Ela gene product, Cell 26:213.

    Article  PubMed  CAS  Google Scholar 

  • Nevins, J.R., 1982, Induction of the synthesis of a 70,000 dalton mammalian heat shock protein by the adenovirus Ela gene product, Cell 29:913.

    Article  PubMed  CAS  Google Scholar 

  • Nevins, J.R., and Darnell, J.E., 1978a, Steps in the processing of Ad2 mRNA: Poly(A)+ nuclear sequences are conserved and poly(A] addition precedes splicing, Cell 15:1477.

    Article  PubMed  CAS  Google Scholar 

  • Nevins, J.R., and Darnell, J.E., 1978b, Groups of adenovirus type 2 mRNA’s derived from a large primary transcript: Probable nuclear origin and possible common 3′ ends,J. Virol. 25:811.

    PubMed  CAS  Google Scholar 

  • Nevins, J.R., and Wilson, M.C., 1981, Regulation of adenovirus-2 gene expression at the level of transcriptional termination and RNA processing, Nature (London) 290:113.

    Article  CAS  Google Scholar 

  • Nevins, J.R., and Winkler, J.J., 1980, Regulation of early adenovirus transcription: A protein product of early region 2 specifically represses region 4 transcription, Proc. Natl. Acad. Sci. U.S.A. 77:1893.

    Article  PubMed  CAS  Google Scholar 

  • Nevins, J.R., Ginsberg, H.S., Blanchard, J.M., Wilson, M.C., and Darnell, J.E., 1979, Regulation of the primary expression of the early adenovirus transcription units.J. Virol. 32:727.

    PubMed  CAS  Google Scholar 

  • Ohe, K., and Weissman, S.M., 1970, Nucleotide sequence of an RNA from cells infected with adenovirus 2, Science 167:879.

    Article  PubMed  CAS  Google Scholar 

  • Osborne, T.F., Gaynor, R.B., and Berk, A.J., 1982, The TATA homology and the mRNA 5′ untranslated sequence are not required for expression of essential adenovirus E1A functions, Cell 29:139.

    Article  PubMed  CAS  Google Scholar 

  • Parsons, J.T., and Green, M., 1971, Resolution of early virus-specific RNA species in adenovirus infected and transformed cells, Virology 45:154.

    Article  PubMed  CAS  Google Scholar 

  • Perricaudet, M., Akusjärvi, G., Virtanen, A., and Pettersson, U., 1979, Structure of two spliced mRNAs from the transforming region of human subgroup C adenoviruses, Nature (London) 281:694.

    Article  CAS  Google Scholar 

  • Perricaudet, M., Le Moullec, J.-M., and Pettersson, U., 1980a, Predicted structure of two adenovirus tumor antigens, Proc. Natl. Acad. Sci. U.S.A. 77:3778.

    Article  PubMed  CAS  Google Scholar 

  • Perricaudet, M., Le Moullec, J.-M., Tiollais, P., and Pettersson, U., 1980b, Structure of two adenovirus type 12 transforming polypeptides and their evolutionary implications, Nature (London) 288:174.

    Article  CAS  Google Scholar 

  • Persson, H., Monstein, H.J., Akusjärvi, G., and Philipson, L., 1981, Adenovirus early gene products may control viral mRNA accumulation and translation in vivo, Cell 23:485.

    Article  PubMed  CAS  Google Scholar 

  • Philipson, L., Wall, R., Glickman, G., and Darnell, J.E., 1971, Addition of polyadenylate sequences to virus-specific RNA during adenovirus replication, Proc. Natl. Acad. Sci. U.S.A. 68:2806.

    Article  PubMed  CAS  Google Scholar 

  • Philipson, L., Pettersson, U., Lindberg, U., Tibbets, C., Vennström, B., and Persson, T., 1974, RNA synthesis and processing in adenovirus-infected cells, Cold Spring Harbor Symp. Quant. Biol. 39:447.

    Article  Google Scholar 

  • Proudfoot, N.J., and Brownlee, G.G., 1974, Sequence at the 3′ end of globin mRNA shows homology with immunoglobulin light chain mRNA, Nature (London) 252:359–362.

    Article  CAS  Google Scholar 

  • Revel, M., and Groner, Y., 1978, Post-transcriptional and translational controls of gene expression in eukaryotes, Annu. Rev. Biochem. 47:1079.

    Article  PubMed  CAS  Google Scholar 

  • Ricciardi, R.P., Jones, R.L., Cepko, C.L., Sharp, P.A., and Roberts, B.E., 1981, Expression of early adenovirus genes requires a viral encoded acidic polypeptide, Proc. Natl. Acad. Sci. U.S.A. 78:6121.

    Article  PubMed  CAS  Google Scholar 

  • Rosa, M.D., Gottlieb, E., Lerner, M.R., and Steitz, J.A., 1981, Striking similarities are exhibited by two small Epstein-Barr virus encoded ribonucleic acids and the adenovirus-associated ribonucleic acid VAI and VAU, Mol. Cell. Biol. 1:785.

    PubMed  CAS  Google Scholar 

  • Sehgal, P., Fraser, N., and Darnell, J., 1979, Early Ad-2 transcription units: Only promoter-proximal RNA continues to be made in the presence of DRB, Virology 94:185.

    Article  PubMed  CAS  Google Scholar 

  • Sergeant, A., Tigges, M.A., and Raskas, H.J., 1979, Nucleosome-like structural subunits of intranuclear parental adenovirus type 2 DNA, J. Virol. 29:888.

    PubMed  CAS  Google Scholar 

  • Sharp, P.A., 1981, Speculations on RNA splicing (minireview), Cell 23:643.

    Article  PubMed  CAS  Google Scholar 

  • Shatkin, A.J., 1976, Capping of eukaryotic RNAs, Cell 9:645.

    Article  PubMed  CAS  Google Scholar 

  • Shaw, A.R., and Ziff, E.B., 1980, Transcripts from the adenovirus-2 major late promoter yield a single family of 3′ coterminal mRNAs during early infection and five families at late times, Cell 22:905.

    Article  PubMed  CAS  Google Scholar 

  • Shaw, A.R., and Ziff, E.B., 1982, Selective inhibition of adenovirus type 2 early region II and III transcription by an anisomycin block of protein synthesis, Mol. Cell. Biol. 2:789.

    PubMed  CAS  Google Scholar 

  • Shenk, T., Jones, N., Colby, W., and Fowlkes, D., 1979, Functional analysis of adenovirus-5 host-range deletion mutants defective for transformation of rat embryo cells, Cold Spring Harbor Symp. Quant. Biol. 44:367.

    Article  Google Scholar 

  • Solnick, D., 1981, An adenovirus mutant defective in splicing RNA from early region 1A, Nature (London) 291:508.

    Article  CAS  Google Scholar 

  • Sommer, S., Salditt-Georgieff, M., Bachenheimer, S., Darnell, J.E., Furuichi, Y., Morgan, M., and Shatkin, A.J., 1976, The methylation of adenovirus-specific nuclear and cytoplasmic RNA, Nucleic Acids Res. 3:749.

    PubMed  CAS  Google Scholar 

  • Spector, D.J., McGrogan, M., and Raskas, H.J., 1978, Regulation of the appearance of cytoplasmic RNAs from region 1 of the adenovirus 2 genome, J. Mol. Biol. 126:395.

    Article  PubMed  CAS  Google Scholar 

  • Stillman, B., Lewis, J., Chow, L., Mathews, M., and Smart, J., 1981, Identification of the gene and mRNA for the adenovirus terminal protein precursor, Cell 23:497.

    Article  PubMed  CAS  Google Scholar 

  • Svensson, C., Pettersson U., and Akusjärvi, G., 1983, Splicing of adenovirus 2 early region 1A mRNAs is nonsequential, J. Mol. Biol. 165:475–495.

    Article  PubMed  CAS  Google Scholar 

  • Tate, V.E., and Philipson, L., 1979, Parental adenovirus DNA accumulates in nucleosome-like structures in infected cells, Nucleic Acids Res. 6:2769.

    Article  PubMed  CAS  Google Scholar 

  • Thimmappaya, B., Weinberger, C., Schneider, R.J., and Shenk, T., 1982, Adenovirus VAI RNA is required for efficient translation of viral mRNAs at late times after infection, Cell 31:543–551.

    Article  PubMed  CAS  Google Scholar 

  • Tooze, J. (ed.), 1980, DNA Tumor Viruses, 2nd rev. ed., Cold Spring Harbor Press, Cold Spring Harbor, New York.

    Google Scholar 

  • Uhlen, M., Svensson, C., Josephson, S., Alestrom P., Chattopadhyay, S., Pettersson, U., and Philipson, U., 1982, Leader arrangement in the adenovirus fiber mRNA, The EMBO Journal 1:249–254.

    PubMed  CAS  Google Scholar 

  • van der Vliet, P.C., and Levine, A.J., 1973, DNA-binding proteins specific for cells infected by adenovirus, Nature (London) New Biol. 246:170.

    Google Scholar 

  • van der Vliet, P.C., Levine, A.J., Ensinger, M., and Ginsberg, H.S., 1975, Thermolabile DNA binding proteins from cells infected with a termperature-sensitive mutant of adenovirus defective in viral DNA synthesis, J. Virol. 15:348.

    Google Scholar 

  • Virtanen, A., and Pettersson, U., 1983, The molecular structure of the 9 S mRNA from early region 1A of adenovirus serotype 2, J. Mol. Biol. 165:496–499.

    Article  PubMed  CAS  Google Scholar 

  • Virtanen, A., Alestrom, P., Persson, H., Katze, M.G., and Pettersson, U., 1982, An adenovirus agno gene, Nucleic Acids Res. 10:2539.

    Article  PubMed  CAS  Google Scholar 

  • Wall, R., Philipson, L., and Darnell, J.E., 1972, Processing of adenovirus specific nuclear RNA during virus replication, Virology 50:27.

    Article  PubMed  CAS  Google Scholar 

  • Weber, J., Blanchard, J.M., Ginsberg, H., and Darnell, J.E., 1980, Polyadenylic acid addition and splicing events in early adenovirus mRNA formation, J. Virol. 33:286.

    PubMed  CAS  Google Scholar 

  • White, D.L., Scharff, M.D., and Maizei, J.U., 1969, The polypeptides of adenovirus. III. Synthesis in infected cells, Virology 38:395.

    Article  PubMed  CAS  Google Scholar 

  • Weil, P.A., Luse, D.S., Segall, J., and Roeder, R.G., 1979, Selective and accurate initiation of transcription at the Ad2 major late promoter in a soluble system dependent on purified RNA polymerase II and DNA, Cell 18:469.

    Article  PubMed  CAS  Google Scholar 

  • Wilson, M.C., and Darnell, J.E., Jr., 1981, Control of messenger RNA concentration by differential cytoplasmic half-life: Adenovirus messenger RNAs from transcription units 1A and 1B, J. Mol. Biol. 148:231.

    Article  PubMed  CAS  Google Scholar 

  • Wilson, M.C., Fraser, N.W., and Darnell, J.E., 1979a, Mapping of RNA initiation sites by high doses of UV irradiation: Evidence for three independent promoters within the left 11% of the Ad-2 genome, Virology 94:175.

    Article  PubMed  CAS  Google Scholar 

  • Wilson, M.C., Nevins, J.R., Blanchard, J.-M., Ginsberg, H.S., and Darnell, J.E., 1979b, Metabolism of mRNA from the transforming region of adenovirus 2, Cold Spring Harbor Symp. Quant. Biol. 44:447.

    Article  Google Scholar 

  • Wolgemuth, DJ., and Hsu, M.-T., 1981, Visualization of nascent RNA transcripts and simultaneous transcription and replication in viral nucleoprotein complexes from adenovirus 2-infected HeLa cells, J. Mol. Biol. 147:247.

    Article  PubMed  CAS  Google Scholar 

  • Yang, V.W., Lerner, M.R., Steitz, J.A., and Flint, S.J., 1981, A small nuclear ribonucleoprotein is required for splicing of adenovirus early RNA sequences, Proc. Natl. Acad. Sci. U.S.A. 78:1371.

    Article  PubMed  CAS  Google Scholar 

  • Zain, S.J., and Roberts, R.J., 1979, Sequences from the beginning of the fiber messenger RNA of adenovirus-2, J. Mol. Biol. 131:341.

    Article  PubMed  CAS  Google Scholar 

  • Zain, S., Sambrook, J., Roberts, R.J., Keller, W., Fried, M., and Dunn, A.R., 1979, Nucleotide sequence analysis of the leader segments in a cloned copy of adenovirus 2 fiber mRNA, Cell 16:851.

    Article  PubMed  CAS  Google Scholar 

  • Ziff, E.B., 1980, Transcription and RNA processing by DNA tumor virus, Nature (London) 287:491–499.

    Article  CAS  Google Scholar 

  • Ziff, E.B., and Evans, R., 1978, Coincidence of the promoter and capped 5′ terminus of RNA from the adenovirus 2 major late transcription unit, Cell 15:1463.

    Article  PubMed  CAS  Google Scholar 

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© 1984 Plenum Press, New York

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Sharp, P.A. (1984). Adenovirus Transcription. In: Ginsberg, H.S. (eds) The Adenoviruses. The Viruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7935-5_5

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  • DOI: https://doi.org/10.1007/978-1-4684-7935-5_5

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