Abstract
A DNA sequence situated in the human genome between Alu-repeat clusters (“Inter-Alu” DNA) is progressively amplified in extrachromosomal DNA, including covalently closed DNA circles, during serial passage of diploid fibroblasts. A single size-class of Inter-Alu circles is also amplified in lymphocytes from 16 of 24 old donors and yet is not detected in cells from 18 young donors.
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Lumpkin, C.K., McGill, J.R., Riabowol, K.T., Moerman, E.J., Reis, R.J.S., Goldstein, S. (1985). Extrachromosomal Circular DNA and Aging Cells. In: Salk, D., Fujiwara, Y., Martin, G.M. (eds) Werner’s Syndrome and Human Aging. Advances in Experimental Medicine and Biology, vol 190. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7853-2_24
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DOI: https://doi.org/10.1007/978-1-4684-7853-2_24
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