Summary
Intrapleural instillation of a suspension of E. coli (0 25:19:12) results in a double sided pulmonary pleuropneumonial and peribronchial inflammation in albino Wistar rats. This infection lasts at least for 3 weeks when being facilitated by estradiolundecylate (10 mg/rat, weekly) and seems therefore to be a suitable model for testing antimicrobial drugs.
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© 1976 Springer Science+Business Media New York
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Krüger, C., Commichau, R., Henkel, W. (1976). Model of Pleuropneumonia in Rats. In: Williams, J.D., Geddes, A.M. (eds) Laboratory Aspects of Infections. Chemotherapy, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7653-8_39
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DOI: https://doi.org/10.1007/978-1-4684-7653-8_39
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