Abstract
Many kinds of organic anions such as long-fatty acids, bilirubin, bile acids and hormones, bind to albumin in the plasma. L-Tryptophan (Trp) also binds to albumin in the plasma, and this property is quite different from those of other amino acids (Macmenamy and Oncley, 1958). Recent studies on the transport of organic anions into liver cells using perfused rat liver have suggested that ligands tightly bound to albumin rather than unbound li-gands are transferred into liver cells readily, and that hepatic uptake of ligands is primarily mediated by the direct interactions between albumin-ligand complexes and the surface of liver cells (Weisigar et al., 1981).
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References
Fehlmann, M., Cam, A.L., and Freychet, P., 1979, Insulin and glucagon stimulation of amino acid transport in isolated rat hepatocytes, J. Biol. Chem., 254: 10431–10437.
Knox, W.E., Yip, A., and Reshelf, L., 1970, L-Tryptophan 2,3-dioxygenase. in: “Methods in Enzymology 17A”, Tabor, H., and Tabor, C.W., eds., Academic Press, New York, London, pp. 415–421.
Macmenamy, R.H., and Oncley, J.L., 1958, The specific binding of L-trypto-phan to serum albumin, J. Biol. Chem. 233: 1436–1447.
Nagase, S., Shimamura, K., and Shumiya, S.,1979, Albumin deficient rat mutant, Science, 205: 590–591.
Sasaki, E., Saito, K., Ohta, Y., Nagamura, Y., Shinohara, R., and Ishiguro, I., 1987, Facilitation of L-tryptophan uptake into rat hepatocytes by albumin, in: “Progress in Tryptophan and Serotonin Research”, Bender, D.A., Joseph, M.H., Kochen, W., and Steinhart, H., eds., de Gruyter, Berlin, pp. 377–380.
Seglen, E.O., 1976, Preparation of isolated rat liver cells, Methods Cell Biol., 13: 29–83.
Smith, S.A., and Pogson, C.I.,1980, The metabolism of L-tryptophan by isolated rat liver cells, Biochem. J., 186: 977–986.
Weisigar, R., Golan, J., and Ockner, R., 1981, Receptor for albumin on the liver cell surface may mediate uptake of fatty acids and other albumin bound substances, Science, 211: 1048–1051.
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© 1991 Plenum Press, New York
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Sasaki, E. et al. (1991). Specific Binding of L-Tryptophan to Serum Albumin and its Function in Vivo. In: Schwarcz, R., Young, S.N., Brown, R.R. (eds) Kynurenine and Serotonin Pathways. Advances in Experimental Medicine and Biology, vol 294. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5952-4_78
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DOI: https://doi.org/10.1007/978-1-4684-5952-4_78
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