Abstract
The primate prefrontal cortex is densely innervated by midbrain dopamine (DA) neurons. Although the function of this mesocortical DA system is not known, it is believed that this catecholamine (CA) fiber system might be involved in certain mental disorders. In the present study, we investigated the CA innervation of the monkey prefrontal cortex by tyrosine hydroxylase (TH) immunohistochemistry, which is thought to be a reliable method to study cortical DA fibers.1 The density of TH-containing fibers was measured by a computer-aided image analysis technique.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
D. A. Lewis, M. J. Campbell, S. L. Foote, M. Goldstein, and J. H. Morrison, The distribution of tyrosine hydroxylase-immunoreactive fibers in primate neocortex is wide spread but regionally specific, J.Neurosci. 7: 279 (1987).
S. Iritani, M. Fujii, and K. Satoh, The distribution of substance P in the cerebral cortex and hippocampal formation: An immunohistochemical study in the monkey and rat, Brain Res.Bull. 22: 295 (1984).
M. Mogi, K. Kojima, and T. Nagatsu, Detection of inactive or less active forms of tyrosine hydroxylase in human adrenals by a sandwich enzyme immunoassay, Anal.Biochem. 138: 125 (1984).
M. Hashimoto, R. Hata, and A. Isomoto, Color analysis method for estimating the oxygen saturation of hemoglobin using an image-input and processing system, Analytical Biochem. 162: 178 (1987).
D. A. Lewis, M. J. Campbell, S. L. Foote, and J. H. Morrison, The monoaminergic innervation of primate neocortex, Human Neurobiol. 5: 181 (1986).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Plenum Press, New York
About this chapter
Cite this chapter
Matsumura, H., Narita, M., Satoh, K., Nagatsu, I. (1990). Computer-Aided Quantitative Analysis of the Distribution of Catecholamine-Containing Fibers in the Primate Prefrontal Cortex. In: Nagatsu, T., Fisher, A., Yoshida, M. (eds) Basic, Clinical, and Therapeutic Aspects of Alzheimer’s and Parkinson’s Diseases. Advances in Behavioral Biology, vol 38A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5844-2_84
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5844-2_84
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5846-6
Online ISBN: 978-1-4684-5844-2
eBook Packages: Springer Book Archive