Abstract
Long-term potentiation (LTP) of synaptic transmission follows a brief high-frequency stimulus delivered to afferent pathways (1). This activity-dependent enhancement of transmission, which can be studied at the behavioral, cellular and molecular level, is thought to play a role in learning and memory (2–4). Our recent work has centered on identifying and localizing intracellular signals responsible for the induction, maintenance and expression of LTP (5,6).
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References
T. V. P. Bliss and T. Lomo, Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J. Physiol. (London) 232, 331 (1973).
T. V. P. Bliss and M. Lynch, in Long-Term Potentiation: Mechanisms and Key Issues. P.W. Landfield and S.A. Deadwyler, Eds ( Liss, New York, 1988 )
R. A. Nicoll, J. Kauer, R. C. Malenka, Current Excitement in Long-term Potentiation Neuron 1, 97 (1988)
T. H. Brown, P. F. Chapman, E. W. Kairiss, C. L. Keenan, Long-Term Synaptic Potentiation Science 242, 724 (1988).
R. Malinow, D. V. Madison, R. W. Tsien, Persistent Protein Kinase Activity Underlying Long-Term Potentiation Nature 335, 820 (1988).
R. Malinow, H. Schulman, R. W. Tsien, Inhibition of Postsynaptic PKC or CaMKII Blocks Induction but not Expression of LTP Science (in press)
G. L. Collingridge, S. J. Kehl, H. McLennan, Excitatory Amino Acids in Synaptic Transmission in the Schaffer Collateral-Commissural Pathway of the Rat Hippocampus. J. Physiol. (London) 334, 33 (1983).
E. W. Harris, A. H. Ganong, and C. W. Cotman Long-Term Potentiation in the Hippocampus Involves Activation of N-methyl-D-aspartate Receptors Brain Res. 323, 132 (1984).
A. B. Jefferson and H. Schulman, Sphingosine Inhibits Calmodulin-dependent Enzymes J. Biol. Chem. 263, 15241 (1988).
Y. A. Hannun and R. M. Bell, Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation Science 243, 500 (1989).
H. Hidaka, M. Inagaki, S. Kawamoto, Y. Sasaki, Isoquinolinesulfonamides, Novel and Potent Inhibitors of Cyclic Nucleotide dependent Protein Kinase and Protein Kinase C Biochemistry 23, 5036 (1984).
J. A. Kauer, R. C. Malenka, R. A. Nicoll, A Persistent Postsynaptic Modification Mediates Long-Term Potentiation in the Hippocampus Neuron 1, 911 (1988)
D. Muller, M. Joly, G. Lynch, Contributions of Quisqualate and NMDA Receptors to the Induction and Expression of LTP Science 242, 1694 (1988).
T. Honore, S. N. Davies, E. J. Fletcher, P. Jacobsen, D. Lodge, and F. E. Nielsen, Quinoxalinediones: Potent Competitive Non-NMDA Glutamate Receptor Antagonists, Science 241, 701 (1988).
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Malinow, R., Tsien, R.W. (1990). Identifying and Localizing Protein Kinases Necessary for LTP. In: Ben-Ari, Y. (eds) Excitatory Amino Acids and Neuronal Plasticity. Advances in Experimental Medicine and Biology, vol 268. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5769-8_33
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DOI: https://doi.org/10.1007/978-1-4684-5769-8_33
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