Abstract
A sudden increase of the physiological temperature (heat shock) elicits in cells a specific sequence of biochemical events designated, on the whole, as “heat shock response”1. Since this response occurs whenever the cells are exposed to adverse, stressing, conditions this behaviour is also generically referred to as stress response.
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References
S. Lindquist, The heat shock response. Annual Rev. Biochem. 55: 1151 (1986)
U.R. Laemmli, Cleavage of structural proteins during the assembly of the head of bacteriophage T 4. Nature (London) 227: 680 (1970)
P.H. O’Farrel, High resolution two dimensional electrophoresis of proteins. J. Biol. Chem. 250: 4007 (1975)
U. Ferrini, R.Falcioni, A. Delpino R. Cavaliere, G. Zupi and P.G. Natali, Heat shock proteins produced by two human melanoma cell lines: absence of correlation with thermosensitivity. Int. J. Cancer 34: 651 (1984)
G.C. Li and J.Y. Mak, Induction of heat shock protein synthesis in murine tumors during the development of thermotolerance. Cancer Res. 45: 3816 (1985)
G.C. Li and A. Laszlo, Thermotolerance in mammalian cells: a possible role for heat shock proteins. In “Changes in Eukaryotic Gene Expression in Response to Environmental Stress”, B.G. Atkinson and D.B. Walden Ed., Academic Press, Orlando, (1985)
J.J. Heikkila, M. Rloc, J. Bury, G.A. Schultz and L.W. Browder, Acquisition of the heat-shock response and thermotolerance during early development of Xenopus laevis. Dev. Biol. 107: 483 (1985)
M. C. Roccheri, M.G. Di Bernardo and G. Giudice, Synthesis of heat shock proteins in developing sea urchins. Dey. Biol. 83: 173 (1981).
G. Graziosi, F. Micali, R. Marzani, F. De Cristini and A. Savioni, Variability of response of early Drosophila embryos to heat shock. J. Exp. Zool. 214: 141 (1980)
G.M. Hahn and G.C. Li, Thermotolerance and heat shock proteins in mammalian cells. Radiation Res. 92: 452 (1982)
J. Landry and P. Chrétien, Relationship between hyperthermia induced heat shock proteins and thermotolerance in Morris hepatoma cells. Can. J. Biochem. Cell Biol. 61: 428 (1983)
E.B. Boon-Niermeijer, J.E.M. Souren and R. Van Wijk, Thermotolerance induced by 2,4-dinitrophenol. Int. J. Hyperthermia 3: 133 (1987).
G.C. Li and A. Laszlo, Amino acid analogs while inducing heat shock proteins sensitize CHO cells to thermal damage. J. Cel. Physiol. 122: 91 (1985)
K. Watson, G. Dunlop and R. Cavicchioli, Mitochondrial and cytoplasmic protein syntheses are not required for heat shock acquisition of ethanol and thermotolerance in yeast. FEBS Letters 172: 299 (1984)
A. Laszlo and G.C. Li, Heat resistant variants of Chinese fibroblasts altered in expression of heat shock protein. Proc. Natl. Acad. 3ci. USA 82: 8029 (1985)
R.L. Anderson, T.W. Tao, D.A. Betten and G.M. Hahn, Heat shock protein levels are not elevated in heat resistant B-16 melanoma cells. Radiation Res. 105: 240 (1986)
R.A. Omar and K.W. Lanks, Heat shock protein synthesis and cell survival in clones of normal and simian virus 40-transformed mouse embryo cells. Cancer Res. 44: 3976 (1984)
G.C. Li and J.Y. Mak, Re-induction of hsp 70 synthesis: an assay for thermotolerance. Int. J. Hyperthermia 5: 382 (1989)
F. Mattei, A. Delpino, A.M. Mileo and U. Ferrini, Absence of acquired thermotolerance in murine tumors unable to increase the expression of heat shock proteins following stress stimuli. Tumori 74: 513 (1988)
T. Yamamori and T. Yura, Genetic control of heat-shock protein synthesis and its bearing on growth and thermal resistance in Escherichia cola K-12. Proc. Natl. Acad. Sci. USA 79: 860 (1982)
M.L. Cunnigham, J.G. Peak and M.J. Peak, Single-strand DNA breaks in rodent and human cells produced by superoxide anion or its reduction products. Mutation Res. 184: 217 (1987)
D.P. Loven, D.E. Leeper and L.W. Oberlay, Superoxide dismutase levels in Chinese hamster ovary cells and ovarian carcinoma cells after hyperthermia or exposure to cycloheximide. Cancer Res. 45: 3029 (1985)
S.W. Carper, J.J. Duffy and E.W. Gerner, Heat shock proteins in thermotolerance and other cellular processes. Cancer Res. 47: 5249 (1987)
E.K Boon-Niermeijer, J.E.M. Souren, A.M. De Waal and R. Van Wijk, Thermotolerance induced by heat and ethanol. Int. J. Hyperthermia 4: 211 (1988)
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© 1990 Plenum Press, New York
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Delpino, A., Mattei, E., Mileo, A.M., Ferrini, U. (1990). Clinical Relevance of Heat Shock Proteins. In: Bicher, H.I., McLaren, J.R., Pigliucci, G.M. (eds) Consensus on Hyperthermia for the 1990s. Advances in Experimental Medicine and Biology, vol 267. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5766-7_59
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DOI: https://doi.org/10.1007/978-1-4684-5766-7_59
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