Abstract
Ryanodine, an alkaloid extracted from the wood of Ryania speciosa, is a specific ligand of the “foot” protein of the triad junction(1) and a modulator of sarcoplasmic reticulum (SR) calcium permeability in both striated and smooth muscles.(2–5) Ryanodine modulates the calcium permeability of sarcoplasmic reticulum terminal cisternae membranes in a complex manner. Depending on its concentration and the experimental conditions employed, ryanodine can either increase or decrease this variable.(2–4) It is important to note that either effect will reduce activation-dependent release of SR calcium in intact muscle cells.(6)
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© 1990 Plenum Press, New York
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Sutko, J.L., Robinson, E., Lattanzio, F.A., Schlatterer, R.G., Deslongchamps, P., Ruest, L. (1990). Pharmacology of the Ryania Alkaloids: The Ester A, a Ryanodine Analog That Only Increases Sarcoplasmic Reticulum Calcium Permeability. In: Hidalgo, C., Bacigalupo, J., Jaimovich, E., Vergara, J. (eds) Transduction in Biological Systems. Series of the Centro de Estudios Científicos de Santiago. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5736-0_32
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DOI: https://doi.org/10.1007/978-1-4684-5736-0_32
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