Abstract
Interest in the pathways of nucleotide metabolism in human lymphocytes was stimulated by the serendipitous observations of Giblett, et al., who found that two inborn errors of purine nucleoside metabolism cause severe impairment of lymphocyte function, while sparing other cell types (1, 2). A genetic deficiency of adenosine deaminase engenders a combined immunodeficiency syndrome (1). A similar deficiency in purine nucleoside phosphorylase is associated with a selective cellular immune deficit (2).
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References
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© 1989 Plenum Press, New York
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Carson, D.A., Piro, L.D., Bruce Wasson, D., Carrera, C.J., Beutler, E. (1989). Activity of 2-Chloro-2′-Deoxyadenosine in Chronic Lymphocytic Leukemia, Hairy Cell Leukemia, and Autoimmune Hemolytic Anemia. In: Mikanagi, K., Nishioka, K., Kelley, W.N. (eds) Purine and Pyrimidine Metabolism in Man VI. Advances in Experimental Medicine and Biology, vol 253A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5673-8_70
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DOI: https://doi.org/10.1007/978-1-4684-5673-8_70
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