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Methylthioadenosine (MeSAdo) Phosphorylase Deficiency in Malignancy

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Progress in Polyamine Research

Abstract

The abnormal growth properties of cancer cells must be mediated finally by changes in specific metabolic pathways. In general, malignant transformation is associated with an increase in the activities of enzymes involved in DNA, RNA, and protein synthesis, and a concomitant decrease in the activities of enzymes that degrade cellular metabolites. However, no specific metabolic pathway has been found that distinguishes normal from malignant cells, or is common to all tumors.

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© 1988 Plenum Press, New York

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Carson, D.A., Nobori, T., Kajander, E.O., Carrera, C.J., Kubota, M., Yamanaka, H. (1988). Methylthioadenosine (MeSAdo) Phosphorylase Deficiency in Malignancy. In: Zappia, V., Pegg, A.E. (eds) Progress in Polyamine Research. Advances in Experimental Medicine and Biology, vol 250. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5637-0_16

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  • DOI: https://doi.org/10.1007/978-1-4684-5637-0_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5639-4

  • Online ISBN: 978-1-4684-5637-0

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