Abstract
Fluoropyrimidine therapy is a corner-stone of chemotherapeutic management of metastatic cancer. Although only about 15% of patients respond to initial single-agent FUra therapy, a greater number may have disease stabilization with comparatively mild toxicity1,2. Fifteen years ago, we reported that continuous intraportal infusion of Fyra in a significant prolonged survival compared to historical controls3. Since then, significant discoveries of the mechanisms of action of FUra and attempts at rational approaches in its application have been made.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
B. Gustaysson and L. O. Hafström, Adjuvant and palliative treatment of colo-rectal cancer with fluorinated pyrimidines - a pharmacological and clinical review, Acta Chir Scand Suppl 504 (1981).
F. Ansfield, J. Klotz, T. Nealon, G. Ramirez, J. Minton, G. Hill, W. Wilson, H. Davis, and G. Cornell, A phase III study comparing the clinical utility of four regimens of 5-fluoruracil, Cancer 39: 34 (1977).
O. Almersjö, L. O. Hafström, and B. Gustaysson, Results of regional portal infusion of 5-fluorouracil to patients with primary and secondary liver cancer, Acta Chir Gyn Fenn 65: 27 (1976).
C. P. Spears, B. G. Gustaysson, M. S. Mitchell, D. Spicer, M. Berne, L. Bernstein, and P. V. Danenberg, Thymidylate synthetase inhibition in malignant tumors and normal liver of patients given intravenous 5-fluorouracil, Cancer Res 44: 4144 (1984).
C. P. Spears, B. G. Gustaysson, and R. Frösing, Folinic acid modulation of fluorouracil: kinetics of bolus administration, Invest New Drugs 6: in press (1988).
C. P. Spears, A. H. Shahinian, R. G. Moran, C. Heidelberger, and T. H. Corbett, In vivo kinetics of thymidylate synthetase inhibition in 5-fluorouracil-sensitive and -resistant murine colon adenocarcinomas, Cancer Res 42:450 (1982).
C. P. Spears and B. G. Gustaysson, Methods for thymidylate synthase pharmacodynamies: serial biopsy, free and total TS, FdUMP and dUMP, and H4PteGlu and CH -H PteGlu assays, in: “The Expanding Role of Folates and Fluoropyrimidines in Cancer Chemotherapy”, Y. Rustum and J. McGuire eds., Plenum Publ Corp, N.Y. (1988).
G. Carlsson, L. Hafström, and B. Gullberg, Estimation of liver tumor volume using different formulas. An experimental study in rats, J Cancer Res Clin Oncol 105: 20 (1983).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Plenum Press, New York
About this chapter
Cite this chapter
Gustaysson, B.G., Carlsson, G., Frösing, R., Spears, C.P. (1988). Pharmacodynamics of 5-Fluorouracil and Leucovorin. In: Rustum, Y., McGuire, J.J. (eds) The Expanding Role of Folates and Fluoropyrimidines in Cancer Chemotherapy. Advances in Experimental Medicine and Biology, vol 244. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-5607-3_23
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5607-3_23
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4684-5609-7
Online ISBN: 978-1-4684-5607-3
eBook Packages: Springer Book Archive