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Cell Calcium Metabolism

Physiology, Biochemistry, Pharmacology, and Clinical Implications

  • Book
  • © 1989

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Editors:
  1. Gary Fiskum

    1. Departments of Biochemistry and Emergency Medicine, The George Washington University School of Medicine and Health Sciences, USA

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Table of contents (63 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Transport and Pharmacology

    1. Front Matter

      Pages 1-1
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    2. Hormonal Inhibition of the Liver Plasma Membrane (Ca2+ —Mg2+ ) ATPase is Mediated by a Gs-like Protein

      • Sophie Lotersztajn, Catherine Pavoine, Ariane Mallat, Dominique Stengel, Paul Insel, Françoise Pecker
      Pages 3-11

    3. The High-Affinity (Ca2+ —Mg2+ )ATPase of Rat Liver Plasma Membrane Hydrolyzes Extracellular ATP

      • Sue-Hwa Lin
      Pages 13-19

    4. The Plasma Membrane Calcium Pump

      • Ernesto Carafoli
      Pages 21-26

    5. The Cardiac Sodium—Calcium Exchange System

      • John P. Reeves, Joo Cheon
      Pages 27-31

    6. Molecular Properties of Dihydropyridine Sensitive Calcium Channels

      • William A. Catterall, Michael J. Seagar, Masami Takahashi, Benson M. Curtis
      Pages 33-45

    7. Monoclonal Antibodies That Coimmunoprecipitate the 1,4-Dihydropyridine and Phenylalkylamine Receptors and Reveal the Ca2+ Channel Structure

      • Michel Fosset, Sylvie Vandaele, Jean-Pierre Galizzi, Jacques Barhanin, Michel Lazdunski
      Pages 47-56

    8. Criteria for Identification of α 1 and α 2 Subunits in a Purified Skeletal Muscle Calcium Channel Preparation

      • Pal L. Vaghy, Kunihisa Miwa, Kiyoshi Itagaki, Ferenc Guba Jr., Edward McKenna, Arnold Schwartz
      Pages 57-64

    9. Phosphorylation of Dihydropyridine-Sensitive Calcium Channels from Cardiac and Skeletal Muscle

      • Christy L. Cooper, Cliff M. O’Callahan, M. Marlene Hosey
      Pages 65-73

    10. Phorbol Esters Stimulate Calcium Influx via Voltage-Dependent Channels in A7r5 Vascular Smooth-Muscle Cells

      • Wilson S. Colucci, Giovanni Sperti
      Pages 75-82

    11. Effects of cAMP-Dependent, Calmodulin-Dependent, and C-Type Protein Kinases on Platelet Calcium Transport

      • William L. Dean, Samuel Evans Adunyah
      Pages 83-91

    12. Molecular Structure of Canine Cardiac Phospholamban, the Regulatory Protein of Ca Pump ATPase of Sarcoplasmic Reticulum

      • Michihiko Tada, Masaaki Kadoma, Junichi Fujii
      Pages 93-101

    13. Ca2+ Transport by Liver and Plant Mitochondria

      • Anibal E. Vercesi, Lucia Pereira-Da-Silva, Ione S. Martins, Eva G. S. Carnieri, Celene F. Bernardes, Marcia M. Fagian
      Pages 103-111

  3. Phosphoinositide Metabolism

    1. Front Matter

      Pages 113-113
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    2. Inositol Lipids and Intracellular Communication

      • Michael John Berridge
      Pages 115-124

    3. Receptor-Mediated Ca2+ Signaling

      • John R. Williamson, Roy A. Johanson, Carl A. Hansen, Jonathan R. Monck
      Pages 125-141

    4. Metabolism of Ins(1,3,4)P3 by Rat Liver Homogenates

      • C. J. Kirk, J. B. Parry, R. F. Irvine, R. H. Michell, S. B. Shears
      Pages 143-148

    5. Evidence for the Existence of the Inositol Tris/Tetrakisphosphate Pathway in Rat Heart

      • D. Renard, J. Poggioli
      Pages 149-156

    6. Mechanisms of Intracellular Calcium Movement Activated by Guanine Nucleotides and Inositol-1,4,5-Trisphosphate

      • Donald L. Gill, Julienne M. Mullaney, Tarun K. Ghosh, Sheau-Huei Chueh
      Pages 157-167
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Keywords

About this book

A widespread appreciation for the role that calcium plays in cell physiology and patho­ physiology has now been achieved due to the pioneering studies of many of the scientists who attended the VIIth International Spring Symposium on Health Sciences at George Washington University in Washington, D. C. The participants in this unique meeting rep­ resented diverse fields of basic and clinical research, such as molecular physiology, oncology, molecular genetics, cardiology, bioenergetics, pathology, and endocrinology. The content of the proceedings of the symposium represents work in these and other areas of biomedical research. Organization of the book is aimed at striking a balance between the biochemistry 2 and physiology of normal cell Ca + metabolism and the pathological consequences of al­ 2 terations in cell Ca + homeostasis. The first section of the book is devoted to the transport mechanisms responsible for 2 2 regulating intracellular Ca + and the pharmacological modalities for controlling cell Ca + . Particular attention is given to the molecular basis for plasma membrane transport activities, 2 2 including the ATP-driven Ca + pump, the Na + -Ca + exchange system, and voltage sensitive 2 Ca + channels. The second section covers the exciting relationships between phosphoinositide metab­ 2 olism, signal transduction, and cell Ca + metabolism. This section begins with an eloquent overview by Professor Michael Berridge, who was the keynote speaker at the symposium and the recipient of the scientific merit award.

Editors and Affiliations

  • Departments of Biochemistry and Emergency Medicine, The George Washington University School of Medicine and Health Sciences, USA

    Gary Fiskum

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