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The Metabolism of Inositol Phosphates

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Cellular and Molecular Aspects of Inflammation

Part of the book series: New Horizons in Therapeutics ((NHTH))

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Abstract

Phosphatidylinositols are phospholipid precursors of a series of inositol phosphates. Several inositol phosphates function as messenger molecules that evoke responses in cells following stimulation by extracellular agonists. While many different compounds are formed, the functions of only a few are understood. The pathways of formation of the inositol phosphates are complex and only partially worked out. The very complexity of the system implies that many functions may be served by these molecules. Myo-inositol (Fig. 1) is a hexatol that can be substituted with various combinations of phosphate esters and 1,2 cyclic phosphate esters. Allowing for all possible combinations of phosphates, we could have as many as 63 distinct noncyclic inositol phosphates and at least 3 cyclic inositol phosphates. Each of these compounds could specify some function, and the amount of information that could be derived from this system is therefore immense. Thus far, 15 inositol phosphates have been described in tissues or extracts of tissues (listed in Table I).

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Authors and Affiliations

  1. Division of Hematology-Oncology, Departments of Internal Medicine and Biological Chemistry, Washington University School of Medicine, St. Louis, Missouri, 63110, USA

    Philip W. Majerus, Thomas M. Connolly, Vinay S. Bansal, Roger C. Inhorn & Hans Deckmyn

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  1. Philip W. Majerus
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  2. Thomas M. Connolly
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  3. Vinay S. Bansal
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  4. Roger C. Inhorn
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  5. Hans Deckmyn
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Editors and Affiliations

  1. Department of Molecular Pharmacology, Smith Kline & French Laboratories, 19101, Philadelphia, Pennsylvania, USA

    George Poste  & Stanley T. Crooke  & 

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© 1988 Plenum Press, New York

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Majerus, P.W., Connolly, T.M., Bansal, V.S., Inhorn, R.C., Deckmyn, H. (1988). The Metabolism of Inositol Phosphates. In: Poste, G., Crooke, S.T. (eds) Cellular and Molecular Aspects of Inflammation. New Horizons in Therapeutics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5487-1_23

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  • DOI: https://doi.org/10.1007/978-1-4684-5487-1_23

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5489-5

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