Abstract
When I was invited to present this lecture, I went through my listing of over 300 articles and found that 62 of those articles were involved with original research papers involving human studies on 40 different drugs. I chose 21 of the 62 articles to present today. Before I discuss individual human studies, I wish to provide some background information.
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References
J.G. Wagner et al, The effect of the dosage form on serum levels of indoxole, Clin. Pharmacol. Ther. 7: 610–619 (1966).
J.G. Wagner et al, Serum concentrations after rectal administration of lincomycin hydrochloride J. Clin. Pharmacol. 8: 154–163 (1968).
J.G. Wagner et al, Absorption, excretion and halflife of clinimycin in normal adult males, Am. J. Med. Sci. 256: 25–37 (1968)/
J.G. Wagner et al, Relative absorption of both tetracycline and penicillin G administered rectally in aqueous solution, Int. J. Clin. Pharmacol. 2: 44–51 (1969).
J.G. Wagner, Some experiences in the evaluation of dosage forms of drugs in man, Compilation of Symposia Papers Presented at the 5th National Meeting of: A.Ph.A. Academy of Pharmaceutical Sciences, American Pharmaceutical Association, Academy of Pharmaceutical Sciences, Washington, D.C., 1970, pp. 420–465.
N. Gerber and J. G. Wagner, Explanation of the dose-dependent decline of diphenylhydantoin plasma levels by fitting to the integrated form of the Michaelis-Menten equation, Res. Comm. Chem. Path. Pharmacol. 3: 455–466 (1972).
J.G. Wagner et al, Equivalence lack in digoxin plasma levels, J. Am. Med. Assoc. 224: 199–204 (1973) .
J.G. Wagner et al, Failure of the USP tablet disintegration test to predict performance in man, J. Pharm. Sci. 62: 859–860 (1973).
J.G. Wagner et al, Importance of the type of dosage form and saturable acetylation in determining the bioactivity of p-aminosalicyclic acid, Am. Rev. Resp. Dis. 108: 536–546 (1973) .
K.S. Albert et al, Plasma concentrations of diphenylhydantoin, its p-hydroxylated metabolite and corresponding glucuronide in man, Res. Comm. Chem. Path. Pharmacol. 9: 463–470 (1974).
K.S. Albert et al, Pharmacokinetics of diphenhydramine in man, J. Pharmacokin. Biopharm. 3: 159–170 (1975).
J.G. Wagner et al, Elimination of alcohol from human blood, J. Pharm. Sci. 65: 152–154 (1976) .
P.K. Wilkinson et al, Blood ethanol concentrations during and following constant-rate intravenous infusion of ethanol, Clin. Pharmacol. Ther. 19: 213–223 (1976) .
Y.-J. Lin et al, Effects of solid food on blood levels of alcohol in man; Res. Comm. Chem. PATH. Pharmacol. 13: 713–722 (1976).
A.V. Tembo et al, Bioavailability of predniso- lone tablets, J. Pharmacokin. Biopharm. 5: 207–224 (1977)
J.W. Ayres et al, Pharmacokinetics of tolmetin with and without concomitant administration of antacid in man, Eur. J. Clin. Pharmacol.
J.W. Ayres et al, Circadian rhythm of urinary pH in man with and without chronic antacid administration, Eur. J. Clin. Pharmacol. 12: 415–420 (1977).
R.F. Bergstrom et al, Penicillamine kinetics in normal subjects, Clin. Pharmacol. Ther. 30: 404–413 (1981)
J.G. Wagner et al, Prediction of steady-state verpamil plasma concentrations in children and adults, Clin. Pharmacol. Ther. 32: 172–181 (1982).
G.F. Lockwood et al, Pharmacokinetics of ibuprofen in man. I. Free and total area/dose relationships, Clin. Pharmacol. Ther. 34: 97–103 (1983).
G.J. Szpunar et al, Pharmacokinetics of flurb- iprofen in man. I. Area/dose relationships. Biopharm. Drug Dispos. accepted October 24, 1986.
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Wagner, J.G. (1988). Pharmacokinetic Studies in Man. In: Pecile, A., Rescigno, A. (eds) Pharmacokinetics. NATO ASI Series, vol 145. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5463-5_14
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DOI: https://doi.org/10.1007/978-1-4684-5463-5_14
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