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Pharmacokinetics

Mathematical and Statistical Approaches to Metabolism and Distribution of Chemicals and Drugs

  • Book
  • © 1988

Overview

Editors:
  1. A. Pecile

    1. Dept. of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Milan, Italy

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  2. A. Rescigno

    1. Institute of Exper. and Clinical Medicine, University of Ancona, Ancona, Italy

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: NATO Science Series A: (NSSA, volume 145)

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-x
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  2. History of Pharmacokinetics

    • Erich Gladtke
    Pages 1-9

  3. Conceptual Foundations and Uses of Models in Pharmacokinetics

    • James S. Beck
    Pages 11-18

  4. Development of Compartmental Concepts

    • Aldo Rescigno, Ajit K. Thakur
    Pages 19-26

  5. Modeling of Pharmacokinetic Data

    • Ajit K. Thakur
    Pages 27-59

  6. Mathematical Foundations of Linear Kinetics

    • Aldo Rescigno
    Pages 61-111

  7. An Introduction to Stochastic Compartmental Models in Pharmacokinetics

    • James H. Matis
    Pages 113-128

  8. Modeling First-Pass Metabolism

    • John G. Wagner
    Pages 129-149

  9. Saturable Drug Uptake by the Liver : Models, Experiments and Methodology

    • Ludvik Bass
    Pages 151-190

  10. Physiological Models, Allometry, Neoteny, Space-Time and Pharmacokinetics

    • Harold Boxenbaum, Richard D’Souza
    Pages 191-214

  11. Equivalence of Bioavailability and Efficacy in Drug Testing

    • Carl M. Metzler
    Pages 215-225

  12. Modeling and Risk Assessment of Carcinogenic Dose-Response

    • Ajit K. Thakur
    Pages 227-244

  13. The Puzzle of Rates of Cellular Uptake of Protein-Bound Ligands

    • Ludvik Bass, Susan M. Pond
    Pages 245-269

  14. A Pharmacokinetic Equation Guide for Clinicians

    • Joyce Mordenti
    Pages 271-289

  15. Pharmacokinetic Studies in Man

    • John G. Wagner
    Pages 291-322

  16. Metabolic Models in Radiation Protection

    • Francesco Breuer
    Pages 323-335

  17. Back Matter

    Pages 337-348
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Keywords

About this book

Pharmacologists can be considered pioneers of the study of kinetics of materials introduced into biological systems. The study of drug kinetics is particularly suited to a formulation of relatively simple models which make possible an interpretation of the time-dependent nature of various important phenomena (e. g. distribution by means of diffu­ sion through membranesl. The objective of the NATO ASI Course on Pharmacokinetics was that of presenting and dis­ cussing the mathematical and statistical approaches current­ ly available or being developed for the description, inter­ pretation and prediction of the fate of drugs and tracer substances administered to living beings. Different physi­ cal methods for measuring drugs and tracer substances were considered, but the emphasis was on the interpretation of the results of the measurements in terms of mathematical and statistical models. The present book contains all invit­ ed lectures given in this Course by outstanding internation­ al authorities and specialists from different fields. A great effort was made to keep a balance among the mathemati­ cal, physical, biological and clinical aspects of the prob­ lems; exchange of ideas and experiences between scientists with a physico-mathematical background and scientists with a biomedical background was encouraged and all participants were deeply involved in fruitful discussions. This unique feature of the Course is also the unique characteristic of this book which is therefore mainly directed to people interested not just in acquiring a working knowledge of the methods but in developing new methods.

Editors and Affiliations

  • Dept. of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Milan, Italy

    A. Pecile

  • Institute of Exper. and Clinical Medicine, University of Ancona, Ancona, Italy

    A. Rescigno

Bibliographic Information

  • Book Title: Pharmacokinetics

  • Book Subtitle: Mathematical and Statistical Approaches to Metabolism and Distribution of Chemicals and Drugs

  • Editors: A. Pecile, A. Rescigno

  • Series Title: NATO Science Series A:

  • DOI: https://doi.org/10.1007/978-1-4684-5463-5

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1988

  • Softcover ISBN: 978-1-4684-5465-9Published: 26 July 2013

  • eBook ISBN: 978-1-4684-5463-5Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: X, 348

  • Topics: Pharmacology/Toxicology

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