Abstract
Acetaminophen overdosage, taken either as a suicidal gesture or as an accidental poisoning, is a significant clinical entity and one that appears to be growing in incidence. Results from a recent study have shown that the percentage of total drug-related deaths associated with acetaminophen in England and Wales rose dramatically from 3.8% in 1973 to 21% in 1980; further, the number of acetaminophen-associated deaths was the highest of all drug-related deaths for the years 1978 to 1980 (1). Thus there is a need to define more clearly the reasons for differences in patient responsiveness and to develop new treatment regimens to decrease the severity of liver failure.
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© 1986 Plenum Press, New York
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Price, V.F., Schulte, J.M., Spaethe, S.M., Jollow, D.J. (1986). Mechanism of Fasting-Induced Suppression of Acetaminophen Glucuronidation in the Rat. In: Kocsis, J.J., Jollow, D.J., Witmer, C.M., Nelson, J.O., Snyder, R. (eds) Biological Reactive Intermediates III. Advances in Experimental Medicine and Biology, vol 197. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5134-4_64
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DOI: https://doi.org/10.1007/978-1-4684-5134-4_64
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