Molecular Aspects of Early Development

1. Front Matter

   Pages i-viii

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2. The Yellow Crescent of Ascidian Eggs: Molecular Organization, Localization and Role in Early Development

   • William R. Jeffery, Craig R. Tomlinson, Richard D. Brodeur, Stephen Meier

   Pages 1-38

3. Expression of Maternal and Embryonic Genes during Sea Urchin Development

   • Bruce P. Brandhorst, Frank Tufaro, Pierre-Andre Bedard

   Pages 39-60

4. Translational Regulation of Gene Expression in Early Development

   • Joan V. Ruderman, Eric T. Rosenthal, Terese Tansey

   Pages 61-86

5. mRNA Distributions in Sea Urchin Embryos

   • Robert C. Angerer, Kathleen J. Hughes, Donna V. DeLeon, David A. Lynn, Lynne M. Angerer

   Pages 87-107

6. Subcellular Localization of Maternal Histone mRNAs and the Control of Histone Synthesis in the Sea Urchin Embryo

   • Richard M. Showman, Dan E. Wells, John A. Anstrom, Deborah A. Hursh, David S. Leaf, Rudolf A. Raff

   Pages 109-130

7. A Family of mRNAs Expressed in the Dorsal Ectoderm of Sea Urchin Embryos

   • William H. Klein, Lisa M. Spain, Angela L. Tyner, John Anstrom, Richard M. Showman, Clifford D. Carpenter et al.

   Pages 131-140

8. Segregation of Germ-Line-Specific Antigens During Embryogenesis in Caenorhabditis Elegans

   • Susan Strome, William B. Wood

   Pages 141-165

9. Genetic and Developmental Approaches to Understanding Determination in Early Development

   • Kenneth D. Konrad, Anthony P. Mahowald

   Pages 167-188

10. Homoeotic Genes and the Specification of Segmental Identity in the Embryo and Adult Thorax of Drosophila Melanogaster

    • Thomas C. Kaufman, Michael K. Abbott

    Pages 189-218

11. Isolation and Characterization of Genes Differentially Expressed in Early Drosophila Embryogenesis

    • Judith A. Lengyel, Steven R. Thomas, Paul David Boyer, Fidel Salas, Teresa R. Strecker, Inyong Lee et al.

    Pages 219-251

12. Accumulation and Behavior of mRNA During Oogenesis and Early Embryogenesis of Xenopus Laevis

    • Linda E. Hyman, Hildur V. Colot, Michael Rosbash

    Pages 253-266

13. Protein Synthesis Patterns During Early Amphibian Embryogenesis

    • Debbie Crise Meuler, George M. Malacinski

    Pages 267-288

14. Changes in Synthesis of RNA and Protein During Reactivation of Delayed Implanting Mouse Blastocysts

    • H. M. Weitlauf

    Pages 289-307

15. Back Matter

    Pages 309-324

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The early embryo has emerged as the focal point for analysis of the regulation of gene expression for several reasons. First, the fact that embryogenesis is under genetic control has been appreciated from the earliest days of classical embryology. When experimental techniques became available it was therefore logical that they should be applied to the embryo. With each new advance in methodology, interest in embryonic gene expression studies has increased. Second, many embryos offer unique opportunities for the investigation of specific aspects of the regulation of gene expression. Several phenomena--eg. , control of translation--can be very conveniently studied in a variety of marine invertebrate embryos. Those embryos contain large stores of maternally inherited mRNA which are translated in a highly ordered fashion during specific stages of post fertilization development. Marine invertebrate eggs can be conveniently artifically inseminated and labeled with radioactive precursors. Their analysis is leading to important insights into the mechanisms which regulate gene expression at post-transcriptional levels. Third, recent advances in both transmission and recombinant DNA genetics, especially in organisms such as Drosophila, are providing special opportunities for the analysis of regulatory mechanisms which operate at the level of the genome. Specific genes have been identified, isolated, and--in some instances--sequenced. The opportunity is now available to study the regulation of the expression of single genes in a vertical fashion--from the primary sequence of the gene to the tissues and organs which are the products of morphogenesis.

• DNA
• Drosophila
• Invertebrate
• Termination
• Vertebrate
• Xenopus laevis
• development
• embryo
• embryology
• gene expression
• genes
• genetics
• morphogenesis
• transcription
• translation

• Indiana University, Bloomington, USA

  George M. Malacinski, William H. Klein

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