Immunology of Clinical and Experimental Diabetes

1. Front Matter

   Pages i-xix

   PDF

2. Experimental Diabetes

   1. Front Matter

      Pages 1-1

      PDF

   2. Structure and Function of Insulin

      • J. E. Pitts, M. Bajaj

      Pages 3-49

   3. Genetic Control of the Immune Response to Insulin in Man and Experimental Animals

      • Alan S. Rosenthal, Dean Mann, C. Ronald Kahn

      Pages 51-71

   4. Virus and Experimental Diabetes

      • H. Müntefering, F. K. Jansen

      Pages 73-89

   5. Animal Models of Human Type I Diabetes

      • Ali Naji, Clyde F. Barker

      Pages 91-112

   6. Immune Function in Obese, Diabetic, Hyperinsulinemic C57BL/KsJ-db+/db+ and C57BL/6J-ob/ob Mice

      • Barry S. Handwerger, Gabriel Fernandes, David M. Brown

      Pages 113-130

   7. The Influence of Sex Hormones on Immunological Processes in the Induction of Diabetes

      • Young Tai Kim, Charles E. Moody Jr.

      Pages 131-145

   8. Transplantation of Pancreas and Islets

      • David E. R. Sutherland, Patricia L. Chinn, Charles E. Morrow

      Pages 147-246

3. Clinical Diabetes

   1. Front Matter

      Pages 247-247

      PDF

   2. Antibodies to Insulin and Insulin Receptors: Mechanisms of Insulin Resistance

      • C. Ronald Kahn

      Pages 249-270

   3. Genetic Basis of Type I (Insulin-Dependent) Diabetes

      • A. G. Cudworth, Eva Wolf

      Pages 271-294

   4. Virus and Insulin-Dependent Diabetes Mellitus

      • S. A. Huber, B. R. MacPherson

      Pages 295-327

   5. Lymphocyte Response in Diabetes Mellitus

      • Sudhir Gupta

      Pages 329-349

   6. Autoimmunity

      • Jørn Nerup, Åke Lernmark, Joanne Scott

      Pages 351-367

   7. Phagocytic Cell Functions in Diabetes Mellitus

      • Michael E. Miller

      Pages 369-383

   8. Circulating Immune Complexes

      • Dinesh Kumar

      Pages 385-399

   9. Insulin Hypersensitivity: Pathogenesis, Diagnosis, and Management

      • Roy Patterson, Leslie C. Grammer, Peter Y. Chen

      Pages 401-414

4. Back Matter

   Pages 415-426

   PDF

During the past 5 years, impressive progress has been made in understanding the etiopathogenesis of expeiimental and clinical diabetes. The rapid progress that has been made in the general field of immunology has made possible new understanding regarding the role of the immune system in the pathogenesis of diabetes. The other two areas in which recent progress has been made in the field of diabetes include genetics and the role of infectious agent(s) in the etiopathogenesis of diabetes. Because of these recent developments, a vast amount of data has been accumulated and published in a number of metabolic, endocrine, immunological, and general medicine journals. The purpose of this book is to consolidate all the available information and present it in its current state. In the present volume, I strive to bring together relevant contributions from leaders in the fields of immunopathology, immunobiology, and genetics. The advancing understanding has in several instances reached the point of clinical applica­ tion. This volume encompasses the entire scope of modem immunology of diabetes mellitus. This volume has been divided into two major parts, Experimental Diabetes and Clinical Diabetes. In the Experimental part are included chapters dealing with the structure and functions of insulin and the immune response to insulin. Spontaneous and experimentally induced models of type I diabetes mellitus are presented. The role of virus(es) in the etiology of experimental diabetes and the influence of sex on experi­ mental diabetes are discussed. The transplantation of pancreas and islets is reviewed in detail.

• Diabetes
• Diabetes mellitus
• Insulin
• Pancreas
• genetics
• immunobiology
• pathogenesis
• pathology
• transplantation
• virus

• Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, Irvine, USA

  Sudhir Gupta

Policies and ethics