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Mechanism of Taurine Natriuresis in Rats

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Kinins V

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 247 A))

Abstract

Taurine, a sulfur containing amino acid, is abundant in many organs and tissues in mammals1. However, its physiological significance has been hardly understood. We reported that daily urinary taurine excretion significantly decreased in patients with essential hypertension, and administration of taurine increased urinary kallikrein and decreased blood pressure2. In the field of experimental hypertension animal, administration of taurine also showed antihypertensive effect in spontaneously hypertensive rats (SHR)3 and in a stroke-prone substrain (SHR-SP)4, in which the deficiency of taurine metabolism was demonstrated3,5. Since urinary kallikrein has a positive correlation with urinary kinin6, it seems that taurine stimulates kallikrein activity to increase the quantity of kinin produced in the kidney.

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References

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Authors and Affiliations

  1. First Department of Internal Medicine, Kinki University School of Medicine, Osakasayama city, Osaka, 589, Japan

    Noriyuki Kohashi, Takanao Okabayashi, Masatsugu Horiuchi, Hisashi Nishiyama, Toshihiko Takenaka & Ryo Katori

Authors
  1. Noriyuki Kohashi
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  2. Takanao Okabayashi
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  3. Masatsugu Horiuchi
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  4. Hisashi Nishiyama
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  5. Toshihiko Takenaka
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  6. Ryo Katori
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Editor information

Editors and Affiliations

  1. Tohoku University School of Medicine, Sendai, Miyagi, Japan

    Keishi Abe

  2. Science University of Tokyo, Tokyo, Japan

    Hiroshi Moriya

  3. The Osaka Foundation for Promotion of Fundamental Medical Research, Otsu, Shiga, Japan

    Setsuro Fujii

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© 1989 Plenum Press, New York

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Kohashi, N., Okabayashi, T., Horiuchi, M., Nishiyama, H., Takenaka, T., Katori, R. (1989). Mechanism of Taurine Natriuresis in Rats. In: Abe, K., Moriya, H., Fujii, S. (eds) Kinins V. Advances in Experimental Medicine and Biology, vol 247 A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9543-4_99

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  • DOI: https://doi.org/10.1007/978-1-4615-9543-4_99

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9545-8

  • Online ISBN: 978-1-4615-9543-4

  • eBook Packages: Springer Book Archive

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