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Attenuation of Atrial Natriuretic Peptide by Kallikrein in Taurine Administered Rats

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Kinins V

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 247 A))

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Abstract

Taurine is a sulfur-containing amino acid abundant in many mammalian organs and reported to have some important roles1. However, physiological meaning is not fully understood. We have been investigating the antihypertensive effects of taurine, especially in relation to natriuresis2. The taurine natriuresis is supposed to be mainly concerned to the activation of the kallikrein-kinin system. This mechanism will be discussed in detail in another chapter in this review by our colleague, Dr. N. Kohashi. By the way, it became realized that atrial natriuretic peptide(ANP) may play some important roles in water-electrolyte balances and the potent natriuretic activity of ANP has been focused recently3,4, because ANP became to be able to be synthesized more easily, after amino acid sequence of ANP was determined5-8. So it may be increasingly important and neccessary to discuss the action of the natriuretic agents such as taurine in relation to ANP. The purpose of this paper is to examine how ANP takes part in the natriuresis induced by taurine and then assess the interaction of ANP and the activated kallikrein-kinin system induced by taurine. According to this purpose, we designed the following three experiments.

  1. 1

    Effect of long term taurine administration on urinary kallikrein, atrial and plasma ANP.

  2. 2

    Acute effect of ANP on natriuresis on rats with long term taurine administration.

  3. 3

    Natriuresis of ANP in taurine administered rats with inhibiting kallikrein activity by aprotinin.

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References

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Authors and Affiliations

  1. First Department of Internal Medicine, Kinki University School of Medicine, Osakasayama, Osaka 589, Japan

    Masatsugu Horiuchi, Noriyuki Kohashi, Hisashi Nishiyama, Toshihiko Takenaka, Hirokazu Kondo & Ryo Katori

  2. Kaken Pharmaceutical Co, Tsukinowa, Ohtsu, Siga, 520-21, Japan

    Makoto Tamura

Authors
  1. Masatsugu Horiuchi
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  2. Noriyuki Kohashi
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  3. Hisashi Nishiyama
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  4. Toshihiko Takenaka
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  5. Hirokazu Kondo
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  6. Ryo Katori
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  7. Makoto Tamura
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Editor information

Editors and Affiliations

  1. Tohoku University School of Medicine, Sendai, Miyagi, Japan

    Keishi Abe

  2. Science University of Tokyo, Tokyo, Japan

    Hiroshi Moriya

  3. The Osaka Foundation for Promotion of Fundamental Medical Research, Otsu, Shiga, Japan

    Setsuro Fujii

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© 1989 Plenum Press, New York

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Horiuchi, M. et al. (1989). Attenuation of Atrial Natriuretic Peptide by Kallikrein in Taurine Administered Rats. In: Abe, K., Moriya, H., Fujii, S. (eds) Kinins V. Advances in Experimental Medicine and Biology, vol 247 A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9543-4_98

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  • DOI: https://doi.org/10.1007/978-1-4615-9543-4_98

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9545-8

  • Online ISBN: 978-1-4615-9543-4

  • eBook Packages: Springer Book Archive

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