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Solvent Proton Nuclear Magnetic Relaxation Dispersion (NMRD) in Solutions of Paramagnetic Macromolecules

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Book cover Advanced Magnetic Resonance Techniques in Systems of High Molecular Complexity

Part of the book series: Progress in Inorganic Biochemistry and Biophysics ((PIBB,volume 2))

Abstract

It has long been realized that the theory describing nuclear relaxation in the presence of unpaired electron(s)-nucleus coupling, while approximately correct for systems where the correlation time for the interaction is determined by molecular tumbling, breaks down in slow rotating systems for a number of reasons (1–8). This inadequacy has severely limited the use of nuclear relaxation data as a source of quantitative structural and dynamic information on paramagnetic macromolecules of biological interest (9,10). One important aspect of this issue would be the understanding of water proton longitudinal relaxation rates as a function of magnetic field (NMRD) in solutions of paramagnetic metalloproteins. With no exceptions, the paramagnetic contribution to such rates is predominantly point-dipolar in origin (4, 11) and therefore potentially informative on the geometry of the water proton-metal ion interaction.

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Authors and Affiliations

  1. Department of Chemistry, University of Florence, Via G. Capponi 7, 50121, Florence, Italy

    Ivano Bertini, Fabrizio Briganti & Claudio Luchinat

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  1. Ivano Bertini
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  2. Fabrizio Briganti
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  3. Claudio Luchinat
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Editors and Affiliations

  1. Department of Chemistry, University of Siena, Siena, Italy

    Neri Niccolai  & Gianni Valensin  & 

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© 1986 Birkhäuser Boston, Inc.

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Bertini, I., Briganti, F., Luchinat, C. (1986). Solvent Proton Nuclear Magnetic Relaxation Dispersion (NMRD) in Solutions of Paramagnetic Macromolecules. In: Niccolai, N., Valensin, G. (eds) Advanced Magnetic Resonance Techniques in Systems of High Molecular Complexity. Progress in Inorganic Biochemistry and Biophysics, vol 2. Birkhäuser Boston. https://doi.org/10.1007/978-1-4615-8521-3_16

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  • DOI: https://doi.org/10.1007/978-1-4615-8521-3_16

  • Publisher Name: Birkhäuser Boston

  • Print ISBN: 978-1-4615-8523-7

  • Online ISBN: 978-1-4615-8521-3

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