Abstract
The Epstein-Barr virus (EBV) of man is a member of a large group of lymphotropic herpesviruses of primates. These viruses have been isolated from prosimians, New World and Old World monkeys, apes, and man. The isolates fall into three groups. The first group includes EBV and related viruses of Old World monkeys and apes. The DNAs of EBV and these viruses of higher primates show a substantial degree of sequence homology (∼ 40%). Moreover, their genomes share a common structure, and are colinear with each other. Their proteins show extensive antigenic cross-reactivity but differences among them can be observed especially in the case of their nuclear antigens. These viruses are B cell tropic and can immortalize B lymphocytes in tissue culture. The viruses of New World monkeys form a second distinct group. These viruses are not related to EBV and the EBV-like viruses but are related to each other an-tigenically and by DNA homology. They have a common genome structure, which is different from that of EBV, and are T cell tropic. These viruses are cytolytic for nonlymphoid cells in vitro and are also capable of immortalizing T cells in tissue culture. Isolation of a third group of primate herpesviruses has been reported from tree shrews, Tupaia glis belangen, a prosimian species. These viruses are differentiated by their characteristic genome structure.
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References
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Rabin, H. (1985). In Vivo Studies of Epstein-Barr Virus and Other Lymphotropic Herpesviruses of Primates. In: Roizman, B., Lopez, C. (eds) The Herpesviruses. The Viruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8021-8_7
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