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Transcriptional and Post-Transcriptional Strategies in Neuroendocrine Gene Expression

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The Molecular Biology of Cell Determination and Cell Differentiation

Part of the book series: Developmental Biology ((DEBO,volume 5))

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Abstract

The developmental and homeostatic control of expression of certain genes in higher eukaryotes is directed by a diverse group of regulatory molecules comprising the neuroendocrine system, which act through specific receptor-mediated events. The precise temporal and spatial expression of genes of this system during development is requisite for the progressively more complex patterns of regulated gene expression that characterize higher eukaryotes. Based on an analysis of the rat and human calcitonin genes, alternative RNA processing represents one developmental strategy used in the neuroendocrine system to direct a tissue-specific pattern of polypeptide production. A second developmental strategy utilized by the neuroendocrine system restricts the expression of genes encoding neuroendocrine peptides to precise groups of cells as a consequence of modulating their transcription. Understanding the molecular mechanisms responsible for generating such patterns of restricted gene expression is likely to provide general insights into the molecular strategies that are critical for development and function of the neuroendocrine system.

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Authors and Affiliations

  1. Howard Hughes Medical Institute, Eukaryotic Regulatory Biology Program, School of Medicine, University of California, San Diego, La Jolla, California, 92093, USA

    Michael Rosenfeld, E. Bryan Crenshaw III, Ronald Emeson, Stuart Leff, Jeffrey Guise, Sergio Lira, Christian Nelson, Charles Nelson & Andrew Russo

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  1. Michael Rosenfeld
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  2. E. Bryan Crenshaw III
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  3. Ronald Emeson
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  4. Stuart Leff
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  6. Sergio Lira
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  7. Christian Nelson
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  8. Charles Nelson
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  1. University of Calgary, Calgary, Alberta, Canada

    Leon W. Browder

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© 1988 Plenum Press, New York

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Rosenfeld, M. et al. (1988). Transcriptional and Post-Transcriptional Strategies in Neuroendocrine Gene Expression. In: Browder, L.W. (eds) The Molecular Biology of Cell Determination and Cell Differentiation. Developmental Biology, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6817-9_11

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  • DOI: https://doi.org/10.1007/978-1-4615-6817-9_11

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