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Metabolic Activation Systems in Vitro for Carcinogen/Mutagen Screening Tests

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Book cover Chemical Mutagens

Abstract

Correlations between the mutagenic and carcinogenic properties of chemicals were weak prior to 1960, but they have strengthened as a result of the discovery that many chemicals undergo various metabolic changes before they become biologically active.(1) Despite the great diversity of chemical structures, most carcinogens/mutagens appear to give rise to electrophilic derivatives (compounds with electron-deficient atoms), which then react with nucleophilic centers (sites with atoms rich in electrons) that are present in cellular constituents. The growing experimental evidence that links the carcinogenic activity of numerous chemicals to their capacity to be converted into electrophilic derivatives, which can react with DNA and other cellular macromolecules and therefore exert a mutagenic effect, has led to the suggestion that there may be a formal relationship between carcinogenesis and mutagenesis.(2)

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Authors and Affiliations

  1. Programme of Environmental Carcinogens and Host Factors, Division of Environmental Carcinogenesis, International Agency for Research on Cancer, F-69372, Lyon Cedex 2, France

    H. Bartsch & C. Malaveille

  2. Department of Pathobiochemical Cell Research, Institute of Medical Science, University of Tokyo, Tokyo 108, Japan

    T. Kuroki

  3. Faculté de Médecine, Ecole de Pharmacie, Université Catholique de Louvain, B-1200, Brussels, Belgium

    M. Roberfroid

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  1. H. Bartsch
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  2. T. Kuroki
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  3. M. Roberfroid
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  4. C. Malaveille
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Editors and Affiliations

  1. National Institute of Environmental Health Science, Research Triangle Park, North Carolina, USA

    Frederick J. de Serres

  2. Associated Universities, Inc., Washington, D.C., USA

    Alexander Hollaender

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© 1982 Plenum Press, New York

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Bartsch, H., Kuroki, T., Roberfroid, M., Malaveille, C. (1982). Metabolic Activation Systems in Vitro for Carcinogen/Mutagen Screening Tests. In: de Serres, F.J., Hollaender, A. (eds) Chemical Mutagens. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6625-0_3

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  • DOI: https://doi.org/10.1007/978-1-4615-6625-0_3

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