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Oxidative Stress and Signal Transduction pp 181–199Cite as

Tyrosine Phosphorylation in Oxidative Stress

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Abstract

Tyrosine phosphorylation is a central regulatory mechanism for cells to transmit signals from cell surface receptors to the nucleus. Signaling pathways involving tyrosine phosphorylation are conserved in diverse organisms ranging from nematodes and fruit flies to humans.1,2 Receptors for a wide variety of growth factors and hormones, including epidermal growth factor (EGF), platelet-derived growth factor (PDGF), insulin, and erthropoietin (EPO) induce cellular tyrosine phosphorylation either directly through intrinsic tyrosine kinase activity or by coupling to cytoplasmic tyrosine kinases (see Refs. 3 and 4 for review). Tyrosine kinases thus play key roles in growth and differentiation. Tyrosine kinases are also important in the functioning of the immune system. Lymphocyte antigen receptors are coupled to cytoplasmic tyrosine kinases, as are receptors for the cytokines that coordinate the response of the immune system.

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Schieven, G.L. (1997). Tyrosine Phosphorylation in Oxidative Stress. In: Forman, H.J., Cadenas, E. (eds) Oxidative Stress and Signal Transduction. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5981-8_8

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  • DOI: https://doi.org/10.1007/978-1-4615-5981-8_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7741-2

  • Online ISBN: 978-1-4615-5981-8

  • eBook Packages: Springer Book Archive

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