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Reactive Oxygen Intermediates as Primary Signals and Second Messengers in the Activation of Transcription Factors

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Oxidative Stress and Signal Transduction

Abstract

Prokaryotic and eukaryotic cells have developed elaborate mechanisms to rapidly respond to changes in their environment by the novel expression of genes. Different forms of cellular stresses constitute primary signals that are transduced via the plasma membrane into the cytoplasm and ultimately stimulate the expression of specific genes in the cell nucleus. Increased production of reactive oxygen intermediates (ROIs), referred to as oxidative stress, was found to be implicated in a variety of distinct cellular stresses, such as heat shock, exposure to ionizing and UV irradiation and environmental pollutants. The products of genes that are newly induced in response to oxidative stress may confer protection against subsequent adversities; repair ROI-mediated damage of cellular components; or serve to signal stress to neighboring cells or cells in other parts of the organism.

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Authors
  1. Klaus Schulze-Osthoff
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  2. Manuel Bauer
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  3. Markus Vogt
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  4. Sebastian Wesselborg
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  5. Patrick A. Baeuerle
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Editors and Affiliations

  1. University of Southern California, USA

    Henry Jay Forman  & Enrique Cadenas  & 

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© 1997 Springer Science+Business Media Dordrecht

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Schulze-Osthoff, K., Bauer, M., Vogt, M., Wesselborg, S., Baeuerle, P.A. (1997). Reactive Oxygen Intermediates as Primary Signals and Second Messengers in the Activation of Transcription Factors. In: Forman, H.J., Cadenas, E. (eds) Oxidative Stress and Signal Transduction. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5981-8_10

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  • DOI: https://doi.org/10.1007/978-1-4615-5981-8_10

  • Publisher Name: Springer, Boston, MA

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