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Brain Activation Studies Using Magnetic Resonance Imaging

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Magnetic Resonance Spectroscopy and Imaging in Neurochemistry

Part of the book series: Advances in Neurochemistry ((ANCH,volume 8))

Summary

The principles underlying functional magnetic resonance imaging (FMRI) are described, with examples of the various approaches that are employed. These include the use of exogenous (invasive) contrast agents such as gadolinium-DTPA and noninvasive endogenous contrast methods (BOLD magnetic resonance imaging, BOLD magnetic resonance spectroscopy, and arterial spin labeling). The advantages and disadvantages of each are discussed, and technical aspects of the implementation are reviewed. Illustrations of the applications of BOLD magnetic resonance imaging being performed in the authors’ MR Unit include investigations of motor tasks, language dominance, verbal working memory, covert verbal fluency, and hallucinations.

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Authors and Affiliations

  1. Department of Clinical Neurosciences, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK

    Steve C. R. Williams, Andrew Simmons & Chris M. Andrew

  2. Departments of Neuroscience and Biostatistics & Computing, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK

    Mick J. Brammer

  3. Departments of Psychological Medicine and Biostatistics & Computing, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK

    Ed T. Bullmore

  4. Department of Biostatistics & Computing, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK

    Sophia Rabe-Hesketh

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  1. Steve C. R. Williams
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  2. Andrew Simmons
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  3. Chris M. Andrew
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  4. Mick J. Brammer
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  5. Ed T. Bullmore
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  6. Sophia Rabe-Hesketh
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Editors and Affiliations

  1. University of Nottingham, Nottingham, England

    Herman Bachelard

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Williams, S.C.R., Simmons, A., Andrew, C.M., Brammer, M.J., Bullmore, E.T., Rabe-Hesketh, S. (1997). Brain Activation Studies Using Magnetic Resonance Imaging. In: Bachelard, H. (eds) Magnetic Resonance Spectroscopy and Imaging in Neurochemistry. Advances in Neurochemistry, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5863-7_10

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  • DOI: https://doi.org/10.1007/978-1-4615-5863-7_10

  • Publisher Name: Springer, Boston, MA

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