Abstract
Hypoxanthine and xanthine determination is necessary in purine metabolism disorders such as xanthine oxidase deficiency. Until now these two compounds have been generally measured by high performance liquid chromatography (HPLC).1 Because of its high efficiency and rapidity,2 capillary electrophoresis (CE) was chosen to develop a method for the determination of hypoxanthine and xanthine in urine to diagnose xanthinuria.
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References
F.T.A. Chen, C.M. Liu, Y.Z. Hsich and J.C. Sternberg, 1991, Capillary electrophoresis-a new analytical tool, Clin. Chem. 37: 14–19.
R. Boulieu, C. Bory and P. Baltassat, 1982, High-performance liquid Chromatographic determination of hy-poxanthine and xanthine in biological fluids, J. chromatogr. 233: 131–140.
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Bory, C., Chantin, C., Boulieu, R. (1998). Capillary Electrophoretic Analysis of Hypoxanthine and Xanthine for the Diagnosis of Xanthinuria. In: Griesmacher, A., Müller, M.M., Chiba, P. (eds) Purine and Pyrimidine Metabolism in Man IX. Advances in Experimental Medicine and Biology, vol 431. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5381-6_146
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DOI: https://doi.org/10.1007/978-1-4615-5381-6_146
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