Abstract
The development of current treatment strategies have failed to improve the prognosis of malignant glioma patients1. Consenquently, gene therapy has been suggested as a novel approach to treat these seriously ill patients2–5.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ammirati M, Galicich JH, Arbit E, Liao Y (1987): Reoperation in the treatment of recurrent intracranial malignant gliomas. Neurosurgery 21:607–614.
Culver KW, Blaese RM (1994): Gene therapy for cancer. TIG 10:174–178.
Oldfield EH, Ram Z, Culver KW, Blaese RM, Devroom HL, Anderson WF (1993):Gene therapy for the treatment of brain tumors using intratumoral transduction with the thymidine kinase gene and intravenous ganciclovir. Hum Gene Ther 4:39–69.
Ram Z, Culver K, Oshiro E, et al (1995): Summary of results and conclusions of the gene therapy of malignant brain tumors: clinicl study. (Abstract). The 63rd Annual Meeting of the American Association of Neurological Surgeons, April 22–27, 1995, Orlando, USA.
Ylä-Herttuala S (1997): Gene therapy for cancer. In:Tumor Invasion: Biological, Clinical and Therapeutical Considerations. Eds. Mikkelsen, Bjerkvig, Laerum, Rosenblum, John Wiley & Sons. (In print).
Moolten FL (1994): Drug sensitivity (“suicide”) genes for selective cancer chemotherapy. Cancer Gene Ther. 1(4):279–287.
Thorsen F, Visted T, Lehtolainen P, Ylä-Herttuala S, Bjerkvig R (1997): Virus Production in a Replication Deficient Retrovirus Packaging Cell Line. Int. J. Cancer. (Accepted).
Yee JK, Miyanohara A, LaPorte P, Bouic K, Burns JC, Friedmann T (1994): A general method for the generation of high-titer, pantropic retroviral vectors: Highly efficient infection of primary hepatocytes. Proc. Natl. Acad. Sci. USA 91:9564–9568.
Poptani H, Puumalainen AM, Gröhn O, Loimas S, Kainulainen R, Ylä-Herttuala S, Kauppinen R: Monitoring Thymidine kinase and Ganciclovir-Induced Changes in Rat Malignant Glioma In Vivo by Nuclear Magnetic Resonance Imaging. Cancer Gene Therapy. Accepted.
Puumalainen AM, Turunen M, Loimas S, Vainio P, Vanninen R, Tyynelä K, Jänne J, Vapalahti M, Ylä-Herttuala S (1997): Thymidine kinase gene therapy and bystander effect in experimental rat glioma model in vivo. (Submitted).
Puumalainen AM, Vapalahti M, Agrawal R, Laukkanen J, Kossila M, Viita H, Vanninen R, Paljärvi L, Ylä-Herttuala S (1997): b-galactosidase gene transfer to human malignant glioma using retro- and adenovirus vectors. (Submitted).
Ylä-Herttuala S, Luoma J, Viita H, Hiltunen T, Sisto T, Nikkari T (1995): Transfer of 15-lipoxygenase gene into rabbit iliac arteries results in the appearance of oxidation-specific lipid-protein adducts characteristic of oxidized low density lipoprotein. J Clin Invest 95:2692–2698.
Bi WL, Parysek LM, Warnick R, Stambrook PJ (1993): In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSVtk retroviral gene therapy. Hum.Gene Ther. 4:725–731.
Laitinen M, Pakkanen T, Donetti E, et al. (1997): Gene transfer into the carotid artery using an adventitial collar. Human Gene Therapy 8:1657–1661.
Laitinen M, Zachary I, Breier G, Pakkanen T, Häkkinen T, Luoma J, Abedi H, Risau W, Soma M, Laakso M, Martin JF, Ylä-Herttuala S (1997): VEGF gene transfer reduces intimai thickening via increased production of nitric oxide in carotid arteries. Human Gene Therapy. In press.
Ram Z, et al. (1994): In vivo transfer of the human interleukin-2 gene: negative tumoricidal results in experimental brain tumors. J Neurosurg. 80:535–540.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer Science+Business Media New York
About this chapter
Cite this chapter
Puumalainen, AM., Vapalahti, M., Ylä-Herttuala, S. (1998). Gene Therapy for Malignant Glioma Patients. In: Walden, P., Trefzer, U., Sterry, W., Farzaneh, F., Zambon, P. (eds) Gene Therapy of Cancer. Advances in Experimental Medicine and Biology, vol 451. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5357-1_78
Download citation
DOI: https://doi.org/10.1007/978-1-4615-5357-1_78
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-7444-2
Online ISBN: 978-1-4615-5357-1
eBook Packages: Springer Book Archive