Abstract
Compared to autologous BMT, an allogeneic transplant can cure hematopoietic malignancies by transfer of donor cells that exert an anti-neoplastic effect called Graft-versus-Leukemia (GVL) (1). This GVL effect is so potent that some patients who relapse after allogeneic bone marrow transplantation can be reinduced into remission by donor lymphocyte infusions (DLI) (2,3). As with an allogeneic transplant, the main side effect of DLI is graft versus host disease (GVHD). The safety of this therapy might be improved by engineering the donor cells to permit their destruction if significant GVHD occurs. To this end, a number of clinical investigators are evaluating a strategy of infusing allogeneic lymphocytes which have been genetically modified by insertion of a latent suicide gene (4–8).
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© 1999 Springer Science+Business Media New York
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Link, C.J., Traynor, A., Seregina, T., Burt, R.K. (1999). Adoptive Immunotherapy for Leukemia: Donor Lymphocytes Transduced with the Herpes Simplex Thymidine Kinase Gene. In: Burt, R.K., Brush, M.M. (eds) Advances in Allogeneic Hematopoietic Stem Cell Transplantation. Cancer Treatment and Research, vol 101. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4987-1_16
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DOI: https://doi.org/10.1007/978-1-4615-4987-1_16
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