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Gastrointestinal Oncology pp 351–382Cite as

The molecular genetics of colonic cancer

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Part of the book series: Cancer Treatment and Research ((CTAR,volume 98))

Abstract

The molecular genetics of tumor initiation and progression is understood better for colonic cancer than for any other human solid tumor. While much remains to be learned regarding the mechanisms that contribute to the altered growth and metastatic properties of colonic epithelial cells, and in particular, how multiple alterations in gene structure and function interact in affecting cell and tissue homeostasis, the advances thus far are being moved into translational research and direct clinical application for diagnosis and prognosis of colon cancer, and new treatment modalities will certainly develop from these areas of investigation. Moreover, the approaches — both conceptual and methodological — that have driven the research in this disease now serve as models for understanding the fundamental process of tumorigenesis in other organs. Thus, the work in colon cancer has established a new paradigm regarding the causes and clinical progression of human cancer, and has already formulated new approaches to clinical management of populations at risk for disease development and of patients with established tumors. Therefore, an understanding of the molecular genetics of colonic tumorigenesis is essential for the practicing oncologist.

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Authors
  1. Leonard H. Augenlicht
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  1. Clinical Investigations Program Robert H. Lurie Comprehensive Cancer Center, Northwestern University Medical School, USA

    Al B. Benson III M.D., F.A.C.P. (Director) (Director)

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© 1998 Springer Science+Business Media New York

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Augenlicht, L.H. (1998). The molecular genetics of colonic cancer. In: Benson, A.B. (eds) Gastrointestinal Oncology. Cancer Treatment and Research, vol 98. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4977-2_13

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  • DOI: https://doi.org/10.1007/978-1-4615-4977-2_13

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