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Evidence for a Carbocation Intermediate in the Enzymatic Transformation of Leukotriene A4 Into Leukotriene B4

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Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 469))

Abstract

Leukotriene (LT) A4 hydrolase is a soluble enzyme that catalyzes the production of 5S,12R-dihydroxy-6, 14-cis-8,10-trans-eicosatetraenoic acid (LTB4) from the transient allylic epoxide 5S-trans-5, 6-oxido-7,9-trans-11,14-cis-eicosatetraenoic acid (LTA4). LTB4 elicits chemotaxis and adherence of leukocytes in only nM concentrations and is regarded as an important chemical mediator in a variety of inflammatory disorders.

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Refferences

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Authors and Affiliations

  1. Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77, Stockholm, Sweden

    Martina Andberg, Mats Hamberg & Jesper Z. Haeggström

Authors
  1. Martina Andberg
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  2. Mats Hamberg
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  3. Jesper Z. Haeggström
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Editor information

Editors and Affiliations

  1. Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth V. Honn

  2. Vanderbilt University School of Medicine, Nashville, Tennessee, USA

    Lawrence J. Marnett

  3. Free University Berlin, Berlin, Germany

    Santosh Nigam

  4. University of California at San Diego, San Diego, California, USA

    Edward A. Dennis

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© 1999 Springer Science+Business Media New York

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Andberg, M., Hamberg, M., Haeggström, J.Z. (1999). Evidence for a Carbocation Intermediate in the Enzymatic Transformation of Leukotriene A4 Into Leukotriene B4 . In: Honn, K.V., Marnett, L.J., Nigam, S., Dennis, E.A. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4. Advances in Experimental Medicine and Biology, vol 469. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4793-8_47

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  • DOI: https://doi.org/10.1007/978-1-4615-4793-8_47

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7171-7

  • Online ISBN: 978-1-4615-4793-8

  • eBook Packages: Springer Book Archive

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