Abstract
Nickel (Ni) compounds have been implicated in elevating the incidence of lung and nasal cancers in numerous epidemiological studies of nickel refinery workers (IARC, 1990; Doll, 1970; Bennett, 1984; Shen, 1994; Langard, 1994). Many different types of cancer have also been induced at the site of exposure in experimental animal models following inhalation or parenteral administration of various Ni compounds (Ottolenghi, 1975; Sunderman, 1981; Sunderman, 1989). Carcinogenic Ni compounds transform primary human and rodent fibroblasts in tissue cultures (Biedermann and Landolph, 1987; Conway and Costa, 1989; Trott et al., 1995). Ni compounds exhibit low mutagenic activity in gene mutation assays but are clastogenic with a preference for genetically inactive heterochromatin (Conway and Costa, 1989).
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Salnikow, K., Zhou, D., Kluz, T., Wang, C., Costa, M. (1999). CAP43. In: Sarkar, B. (eds) Metals and Genetics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4723-5_9
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DOI: https://doi.org/10.1007/978-1-4615-4723-5_9
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