Abstract
Genetics and biochemical studies show direct involvement of molecular chaperones in the replication of many prokaryotic replicons. The best-studied examples are bacteriophages λ and Mu, plasmids P1, F and RK2, and DNA replication of the Escherichia coli chromosome initiating at the oriC sequence. From a historical point of view, bacteriophage λ DNA replication was the first system in which the synergistic and cooperative action of the DnaK/DnaJ/GrpE molecular chaperone machine was demonstrated [for review see (1, 2)]. This cooperative action is now a paradigm for our understanding of fundamental biochemical processes, such as protein folding, intracellular protein translocation, selective proteolysis and autoregulation of the heat shock response [for review see (3, 4)]. The λ in vitro DNA replication system was also the first functional assay for purification of active DnaK, DnaJ and GrpE proteins (5–8). In this review we are going to discuss the molecular mechanisms of chaperone action during bacteriophage, plasmid and bacterial chromosome DNA replication.
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Konieczny, I., Zylicz, M. (1999). Role of Bacterial Chaperones in DNA Replication. In: Setlow, J.K. (eds) Genetic Engineering. Genetic Engineering, vol 21. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4707-5_6
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