Abstract
β2 integrins (Leu-CAMs, CD11/CD18) are three heterodimeric surface membrane glycoprotein receptors which mediate a large number of divalentcation- dependent cell-cell and cell-matrix adhesion functions in leukocytes.1 Each heterodimer (Figure 1) consists of a distinct ex subunit (CD11a, CD11b or CD11c) noncovalently associated with a single β subunit (CD18). CD11a/CD18 is expressed on all leukocytes. CD11b and CD11c expression is restricted to myelomonocytic cells and NK cells.
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Arnaout, M.A., Michishita, M., Sharma, C.P. (1992). On the Regulation of β2 Integrins. In: Gupta, S., Waldmann, T.A. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation IV. Advances in Experimental Medicine and Biology, vol 323. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3396-2_22
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DOI: https://doi.org/10.1007/978-1-4615-3396-2_22
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