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The role of growth factors in angiogenesis

  • Chapter
Growth Factors and the Cardiovascular System

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 147))

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Abstract

Although a role for growth factors in angiogenesis was first recognized in 1971 an explosion in growth factor identification and characterization has occurred over the last 5 years. Widespread use of recombinant DNA technology has led to the identification of new peptide growth factors (and in many cases their receptors) which are capable of stimulating angiogenesis. For example, the family of Heparin Binding Growth Factors (HBGF’s), which includes Fibroblast Growth Factor (FGF), has had five new members identified since 1987, bringing the total in 1992 to seven. There are currently four receptors for the HBGF family which have been identified and partially characterized. Despite cloning and in vitro characterization of growth factors, their contribution to developmental, physiologic or pathologic angiogenesis remains largely speculative [1]. Growth factors are considered angiogenic on the basis of in vitro or biologic assays, but the in vivo activity of any particular growth factor appears to be contextual, i.e. modulated by the presence of other growth factors, as well as the extracellular milieu and participating cell types [2]. Angiogenesis is a complex process shaped by the interplay of stimulatory and inhibitory factors, the choreography of which is an important subject for angiogenesis research.

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  1. Robert J. Schott
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  2. Linda A. Morrow
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  1. Department of Physiology, University of Birmingham School of Medicine, Birmingham, UK

    Peter Cummins

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Schott, R.J., Morrow, L.A. (1993). The role of growth factors in angiogenesis. In: Cummins, P. (eds) Growth Factors and the Cardiovascular System. Developments in Cardiovascular Medicine, vol 147. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3098-5_9

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  • DOI: https://doi.org/10.1007/978-1-4615-3098-5_9

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