Abstract
Tetrahydrobiopterin (BH4) has been used for the therapy of BH4-deficient patients. However, BH4 is poorly absorbed from the intestine. The plasma level of biopterin that was reached after oral administration of BH4 to a BH4-deficient patient was reported to be 1–2% of the levels reached after either intravenous or subcutaneous administration1. This poor absorption from the intestine needs a large amount of BH4 for the oral therapy, leading to high costs.
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References
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© 1993 Springer Science+Business Media New York
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Sawada, Y. et al. (1993). Oral Administration of Liposomally Entrapped Tetrahydrobiopterin. In: Ayling, J.E., Nair, M.G., Baugh, C.M. (eds) Chemistry and Biology of Pteridines and Folates. Advances in Experimental Medicine and Biology, vol 338. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2960-6_55
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DOI: https://doi.org/10.1007/978-1-4615-2960-6_55
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