Abstract
The transvascular migration of lymphocytes and other leukocytes from blood to peripheral tissues is preceded by adherence of these cells to endothelial cells (EC) lining the vasculature. These adhesive interactions utilize specific molecules (e.g., integrins) on the surfaces of leukocytes and EC. In many cases, the expression of these molecules has been linked to organ-specific homing of lymphocytes (1). Many central nervous system (CNS) disorders such as experimental allergic encephalomyelitis (EAE) and multiple sclerosis (MS) are characterized by the increased infiltration of peripheral blood leukocytes into the CNS. The enhanced adhesive interactions between leukocytes and cerebrovascular EC, which constitute the blood-brain barrier (BBB), may be a mechanism partially responsible for the enhanced transmigration of the BBB observed in these disorders. For example, various adhesion molecules have been indicated to play a role in the pathogenesis of EAE and MS (2, 3).
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McCarron, R.M., Wang, L., Racke, M.K., McFarlin, D.E., Spatz, M. (1993). Effect of Cytokines on ICAM Expression and T Cell Adhesion to Cerebrovascular Endothelial Cells. In: Drewes, L.R., Betz, A.L. (eds) Frontiers in Cerebral Vascular Biology. Advances in Experimental Medicine and Biology, vol 331. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2920-0_37
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DOI: https://doi.org/10.1007/978-1-4615-2920-0_37
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