Abstract
Sjogren’s Syndrome (SS) is an immunologic disease occurring predominantly in women that is associated with severe dry eyes and disabling ocular irritation. SS has been reported to be the most common immunologic disease next to rheumatoid arthritis, and has an estimated prevalence of 1.2 million patients in the United States (based on a reported prevalence of 0.4% in Sweden1).
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References
Manthorpe R, Axell T, Hansen B et al., 1991, Prevalence of primary Sjogren’s syndrome in patients with multiple sclerosis. Clin Exp Rheumatol. 9:326 (Abstract).
Pepose JS, Akata RF, Pflugfelder SC, Voight W., 1990, Mononuclear cell phenotypes and immunoglobulin gene rearrangements in lacrimal gland biopsies from patients with Sjogren’s syndrome. Ophthalmology. 97:1599–1605.
Crouse CA, Pflugfelder SC, Cleary T, et al., 1990, Detection of Epstein-Barr virus genomes in normal human lacrimal glands. J Clin Microbiol. 28:1026–1032.
Wolf H, Haus M, Wilmes E., 1984, Persistence of Epstein-Barr virus in the parotid gland. J Virol. 51:795–798.
Saito I, Servenius B, Compton T, Fox RI., 1989, Detection of Epstein-Barr virus DNA by polymerase chain reaction in blood and tissue biopsies from patients with Sjogren’s syndrome. J Exp Med. 169:2191–8.
Venables PJW, Teo CG, Baboonian C, Griffin BE, Hughes RA., 1989, Persistence of Epstein-Barr virus in salivary gland biopsies from healthy individuals and patients with Sjogren’s syndrome. Clin Exp Immunol. 75:359–364.
Mariette X, Golzan J, Clerc D, Bisson M, Morinet F., 1991, Detection of Epstein-Barr virus DNA by in situ hybridization and polymerase chain reaction in salivary gland biopsy specimens from patients with Sjogren’s syndrome. Am J Med. 90:286–294.
Deacon EM, Matthews JB, Potts AJC, Hamburger J, Bevan JS, Young LS., 1991, Detection of Epstein-Barr virus antigens and DNA in minor salivary glands using immunohistochemistry and polymerase chain reaction: possible relationship to Sjogren’s syndrome. J Pathol. 163:351–360.
Whittingham S, McNeilage J, Mackay IR., 1985, Primary Sjogren’s syndrome after infectious mononucleosis. Ann Intern Med. 102:490–3.
Pflugfelder SC, Roussel TJ, Culbertson WW., 1987, Primary Sjogren’s syndrome after infectious mononucleosis (letter) JAMA. 257:1049–50.
Gaston JSH. Rowe M, Bacon P., 1990, Sjogren’s syndrome after infection by Epstein-Barr virus. J Rheumatol. 17:558–61.
Yen M, Pflugfelder SC, Crouse CA, Atherton SS., 1992, Cytoskeletal antigen expression in ocular mucosal associated lymphoid tissue. Invest Ophthalmol Vis Sci., 33:3235–3241.
Wieczorek R, Jakobiec FA, Sacks EH, Knowles DM., 1988, The immunoarchitecture of the normal human lacrimal gland: relevancy for understanding pathologic conditions. Ophthalmology. 95:100–9.
Monroy D, Pflugfelder SC., 1993, Immunohistochemical analysis of Blymphoproliferation and epithelial pathology in Sjogren’s syndrome lacrimal glands. Invest Ophthalmol vis Sci [ARVO Abstracts; (in press)].
Pflugfelder SC, Crouse CA, Monroy D, et al., 1993, Epstein-Barr virus and the lacrimal gland pathology of Sjogren’s syndrome. Am J Pathol (in press)
Rickinson AB. On the biology of Epstein-Barr virus persistence: A reappraisal, in: Immunobiology and Propylaxis of Herpesvirus Infections, C. Lopez, ed. Plenum Press. New York 1990, pp 137–146.
Moss DJ, Misko IS, Sculley TB, et al., 1991. Immune regulation of Epstein-Barr virus (EBV); EBV nuclear antigen as a target for EBV-specific T cell lysis. Springer Semin Immunopathol. 13:147–156.
Pagano JS., 1992, Epstein-Barr virus: culprit or consort. N Engl J Med. 24:1751–1753.
Randhawa PS, Jaffe R, Demetris AJ, et al., 1992, Expression of Epstein-Barr virus-encoded small RNA (by the EBER1 gene) In liver specimens from transplant recipients with post-transplantation lymphoproliferative disease. N Engl J Med. 327:1710–1714.
Sixbey JW, Nedrud JG, Raab-Traub N, et al., 1984, Epstein-Barr virus replication in oropharyngeal epithelial cells. N Engl J Med. 310:1225–1230.
Sixbey JW, Lemon SM, Pagano JS., 1986, A second site for Epstein-Barr virus shedding: the uterine cervix. Lancet. 2:1122–1124.
Crouse CA Pflugfelder SC, Pereira I et al., 1990, Detection of herpes virus genomes to normal and diseased corneal epithelium. Current Eye Res. 9:569–581.
Pflugfelder SC, Tseng SCG, Pepose JS et al., 1990, Chronic Epstein-Barr viral infection and immunologic dysfunction to patients with aqueous tear deficiency. Ophthalmology. 97:313–323.
Pflugfelder SC, Crouse C, Pereira I, Atherton SS., 1990, Amplification of Epstein-Barr virus genomic sequences in blood cells, lacrimal glands, and tears from primary Sjogren’s syndrome patients. Ophthalmology. 97:976–984.
Tsubota K, Fujishima H, Toda I, Nishimura S, Saito I, Moro I., 1991, Increased level of Epstein-Barr virus DNA in lacrimal and salivary glands of patients with sjogren’s syndrome. Invest Ophthalmol Vis Sci (ARVO abstracts) 32:807.
Sixbey JW, Shirley P, Sloas M, Raab-Traub N., Israele V., 1991, A transformation-incompetent, nuclear antigen 2-deleted Epstein-Barr virus associated with replicative infection. J Infect Dis. 163:1008–1015.
Font RL, Yanoff M, Zimmerman LE., 1967, Benign lymphoepithelial lesion of the lacrimal gland and its relationship to Sjogren’s syndrome. Am J Clin Pathol 48:365–76.
Weiss LM, Gaffey MJ, Shibata D., 1991, Lymphoepithelioma-like carcinoma and its relationship to Epstein-Barr virus (Editorial). Am J Clin Pathol. 96:156–158.
Murray RJ, Young LS, Calender A, Gregory CD, Rowe M, Lenoir GM, Rickinson AB., 1988, Different patterns of Epstein-Barr virus gene expression and of cytotoxic T-cell recognition in B-cell lines infected with transforming (B95-8) or nontransforming (P3HR1) virus strains. J Virol. 62:894–901.
Moss DJ, Misko LS, Burrows SR, Burman K, McCarthy R, Sculley TB., 1988, Cytotoxic T-cell clones discriminate between A- and B-type Epstein-Barr virus transformants. Nature. 331:719–721.
Misko IS, Schmidt C, Honeyman M, Soszynski TD, Sculley TB, Burrows SR, Moss DJ, Burman K., 1992, Failure of Epstein-Barr virus-specific cytotoxic T lymphocytes to Iyse B cells transformed with the B95-8 strain is mapped to an epitope that associates with the HLA B8 antigen. Cin Exp Immunol. 87:65–71.
Arnett FC, Bias WB, Reveille JD., 1989, Genetic studies in Sjogren’s syndrome and systemic lupus erythematosis. J Autoimmunity. 2:403–413.
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Pflugfelder, S.C., Crouse, C.A., Atherton, S.S. (1994). Epstein-Barr Virus and the Lacrimal Gland Pathology of Sjögren’s Syndrome. In: Sullivan, D.A. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes. Advances in Experimental Medicine and Biology, vol 350. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2417-5_107
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DOI: https://doi.org/10.1007/978-1-4615-2417-5_107
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