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About this book
In the past decade, the global efforts in the control of HIV disease were basically concentrated on the search for anti-retroviral agents. So far, anti-HIV therapies have been shown to be disappointing because of rapid development of drug-resistant mutant variants. Despite this drawback in the therapeutic fight against HIV infection, antiviral research should be actively pursued. However, failure of antiviral therapy indicates that other avenues of research should be rapidly explored with the same energy. In this setting, striking advances have been recently made in the dissection and understanding of the viro-immunological processes governing the progressive destruction of lymphoid organs associated with AIDS develop ment, and HIV-induced activation and apoptosis have been identified as key phenomena of the immune system destruction. This book assembles the most recent advances on basic and clinical aspects ofT-cell activationiapoptosis in HIV infection and their implications for immunotherapy. These data were presented at an international symposium held on July 11-12, 1994, in Paris. The book is partitioned into 21 chapters covering four comprehensive fields: 1) T-celllmacrophage activation and HIV infection; 2) Apoptosis and viropathogenesis of HI V disease; 3) Apop tosis and immunopathogenesis ofHIV disease; 4) Mediators ofT-cell activationiapoptosis and therapeutic applications. We hope that this book will assist the readers in understanding recent advances in the viro-immunopathogenesis of HI V disease as well as the rationales for potential immune cell-targeted therapeutic interventions.
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Keywords
Table of contents (21 chapters)
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Front Matter
Editors and Affiliations
Bibliographic Information
Book Title: Cell Activation and Apoptosis in HIV Infection
Book Subtitle: Implications for Pathogenesis and Therapy
Editors: Jean-Marie Andrieu, Wei Lu
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-1-4615-1995-9
Publisher: Springer New York, NY
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eBook Packages: Springer Book Archive
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1995
Hardcover ISBN: 978-0-306-45063-1Published: 30 June 1995
Softcover ISBN: 978-1-4613-5823-7Published: 21 October 2012
eBook ISBN: 978-1-4615-1995-9Published: 06 December 2012
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: XI, 245
Topics: Immunology, Medical Microbiology, Plant Sciences, Animal Anatomy / Morphology / Histology, Microbial Ecology