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Clinically Relevant Resistance in Cancer Chemotherapy pp 211–235Cite as

Model Studies of Cyclophosphamide Resistance in Human Myeloid Leukemia

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Part of the book series: Cancer Treatment and Research ((CTAR,volume 112))

Abstract

Cyclophosphamide (CP), 4-hydroperoxycyclophosphamide (4HC), mafosfamide, and ifosphamide are antineoplastic alkylating agents collectively referred to as oxazaphosphorines. Oxazaphosphorines are used in the treatment of many types of cancer, including neo-adjuvant, adjuvant and high-dose treatment for breast tumors, salvage chemotherapy for a variety of solid tumors, and high-dose conditioning therapy of patients undergoing hematopoietic stem cell transplantation1, 2. In the latter context, these drugs are widely used for the treatment of myeloid leukemias, which represent the focus of this chapter

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Authors and Affiliations

  1. Department of Blood and Marrow Transplantation, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

    Borje S. Andersson

  2. Division of Experimental Oncology, Department of Oncology, University of Alberta and Department of Experimental Oncology, Edmonton, Alberta, Canada

    David Murray

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  1. Borje S. Andersson
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Editors and Affiliations

  1. MD Anderson Cancer Center, Houston, Texas, USA

    Borje Andersson M.D., Ph.D

  2. Cross Cancer Institute, Edmonton, Alberta, Canada

    David Murray Ph.D

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Andersson, B.S., Murray, D. (2002). Model Studies of Cyclophosphamide Resistance in Human Myeloid Leukemia. In: Andersson, B., Murray, D. (eds) Clinically Relevant Resistance in Cancer Chemotherapy. Cancer Treatment and Research, vol 112. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1173-1_11

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  • DOI: https://doi.org/10.1007/978-1-4615-1173-1_11

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