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Progress in Basic and Clinical Immunology pp 317–324Cite as

Presence and functions of immune components in the tumor microenvironment

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 495))

Abstract

There is ample evidence that alterations in oncogenes and tumor suppressor genes are causally involved in malignant transformation (1-3). In addition to alterations in these class I cancer genes (4), changes in the expression of numerous genes whose DNA was not altered i.e. class II cancer genes (4), play crucial roles in tumorigenesis and in tumor progression. Among the important class II cancer genes are proteases, angiogenic factors and angiogenesis inhibitors, cytokines and chemokines and their receptors as well as various adhesion molecules (5-8). It seems that class II cancer genes play a more significant role in the process of tumor progression than in cellular transformation and primary tumorigenesis (4).

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Author information

Authors and Affiliations

  1. Department of Cell Research and Immunology, Tel Aviv University, Tel Aviv, 69978, Israel

    Isaac P. Witz

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  1. Isaac P. Witz
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Editors and Affiliations

  1. GreatPoland Cancer Center, University School of Medical Sciences, Poznan, Poland

    Andrzej Mackiewicz

  2. Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland

    Maciej Kurpisz

  3. Department of Immunology, University School of Medical Sciences, Poznan, Poland

    Jan Żeromski

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Witz, I.P. (2001). Presence and functions of immune components in the tumor microenvironment. In: Mackiewicz, A., Kurpisz, M., Żeromski, J. (eds) Progress in Basic and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 495. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0685-0_44

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  • DOI: https://doi.org/10.1007/978-1-4615-0685-0_44

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5194-8

  • Online ISBN: 978-1-4615-0685-0

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