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The Secretory Immunoglobulin System: Regulation and Biological Significance

Focusing on human mammary glands

  • Chapter
Book cover Integrating Population Outcomes, Biological Mechanisms and Research Methods in the Study of Human Milk and Lactation

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 503))

Abstract

The surface of mucosal epithelia amounts to some 400 m2 in an adult individual. This extensive and generally quite vulnerable barrier is protected by numerous innate mechanisms that cooperate intimately with specific mucosal immunity. The main humoral mediators of this local immune system are secretory IgA (SIgA) and IgM (SIgM); the former class of antibodies constitutes the largest noninflammatory defense system of the body.1,2 Although the secretory antibody system is mainly directed against colonization of pathogens and penetration of “dangerous” antigens, it is also involved in immune exclusion of innocuous soluble proteins present in food (Figure 1). However, the latter type of antigen, as well as components of the indigenous microflora, generally induce poorly understood suppressive mechanisms collectively called oral tolerance when induced via the gut.3,4 This complex phenomenon of mucosally induced immunological downregulation apparently explains why most individuals show no adverse immune reactions to persistent contact with food proteins and the normal microbial flora.

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Authors and Affiliations

  1. Laboratory for Immunohistochemistry and Immunopathology (LIIPAT), Institute of Pathology, University of Oslo, Rikshospitalet, N-0027, Norway

    Per Brandtzaeg

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  1. Per Brandtzaeg
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Editors and Affiliations

  1. Centers for Disease Control and Prevention, Atlanta, Georgia, USA

    Margarett K. Davis

  2. New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, USA

    Charles E. Isaacs

  3. University of Göteborg, Göteborg, Sweden

    Lars Å. Hanson

  4. University of Arizona, Tucson, Arizona, USA

    Anne L. Wright

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© 2002 Springer Science+Business Media New York

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Brandtzaeg, P. (2002). The Secretory Immunoglobulin System: Regulation and Biological Significance. In: Davis, M.K., Isaacs, C.E., Hanson, L.Å., Wright, A.L. (eds) Integrating Population Outcomes, Biological Mechanisms and Research Methods in the Study of Human Milk and Lactation. Advances in Experimental Medicine and Biology, vol 503. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0559-4_1

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  • DOI: https://doi.org/10.1007/978-1-4615-0559-4_1

  • Publisher Name: Springer, Boston, MA

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  • Online ISBN: 978-1-4615-0559-4

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