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Phenotypic Overlap between Monocytes and Vascular Endothelial Cells

  • Chapter
Book cover Novel Angiogenic Mechanisms

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 522))

Summary

During embryonic development, endothelial cells (ECs) develop organ specific properties. ECs express specific markers, which are helpful in identifying these cells in vivo and in culture. Interestingly, most of the supposed specific endothelial markers are present on both ECs and hematopoietic precursors or mature blood cells, which correspond to the idea of a common embryonic precursor. Monocytes/makrophages and monocyte-derived dendritic cells, as more differentiated hematopoietic cell populations, show a wide phenotypic overlap with particularly hepatic sinusoidal, and microvascular endothelial cells within inflamed tissue, such as neovascularizised complicated atherosclerotic plaques. Furthermore, under local angiogenic growth conditions monocytes or monocyte precursors or immature dendritic cells may differentiate into endothelial like cells. First evidence suggests an endothelium-independent revascularization potential carried by monocyte-derived macrophages. These macrophages have been shown to form tunnel-like structures in ischemic regions. Future studies have to address the question, whether monocyte-/dendritic cell-derived endothelial like cells can develop a similar functional behaviour in vasoregulation, coagulation and fibrinolysis, as described for vascular endothelial cells, and thus may contribute to neoangiogenesis by a direct vessel-forming role.

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Authors and Affiliations

  1. Department of Cardiology Medical Clinic II, University of Technology Dresden, Fetscherstr. 76, D-01307, Dresden, Germany

    Ruth H. Strasser MD

  2. Medical Clinic II, Friedrich Alexander University, Erlangen-Nuernberg, Oestliche Stadtmauerstr. 29, D-91054, Erlangen, Germany

    Christiane Graffy & Werner G. Daniel

Authors
  1. Alexander Schmeisser
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  2. Christiane Graffy
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  3. Werner G. Daniel
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  4. Ruth H. Strasser MD
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Editors and Affiliations

  1. The Ohio State University, Columbus, Ohio, USA

    Nicanor I. Moldovan Ph.D.

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© 2003 Springer Science+Business Media New York

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Schmeisser, A., Graffy, C., Daniel, W.G., Strasser, R.H. (2003). Phenotypic Overlap between Monocytes and Vascular Endothelial Cells. In: Moldovan, N.I. (eds) Novel Angiogenic Mechanisms. Advances in Experimental Medicine and Biology, vol 522. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0169-5_7

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  • DOI: https://doi.org/10.1007/978-1-4615-0169-5_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4951-8

  • Online ISBN: 978-1-4615-0169-5

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