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Systems Analysis of Human Multigene Disorders

  • Book
  • © 2014

Overview

Editors:
  1. Natalia Maltsev

    1. University of Chicago, Chicago, USA

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  2. Andrey Rzhetsky

    1. University of Chicago, Chicago, USA

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  3. T. Conrad Gilliam

    1. University of Chicago, Chicago, USA

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  • High-throughput experimental genomics technologies for data collection
  • Bioinformatics approaches for systems-level analysis of biological systems and prediction of causative multidimensional patterns of inheritance characteristic of multigene disorders
  • Case scenarios of systems-level analysis of multigene disorders

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 799)

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About this book

Understanding the genetic architecture underlying complex multigene disorders is one of the major goals of human genetics in the upcoming decades. Advances in whole genome sequencing and the success of high throughput functional genomics allow supplementing conventional reductionist biology with systems-level approaches to human heredity and health as systems of interacting genetic, epigenetic, and environmental factors. This integrative approach holds the promise of unveiling yet unexplored levels of molecular organization and biological complexity. It may also hold the key to deciphering the multigene patterns of disease inheritance.

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Table of contents (5 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Wellness and Health Omics Linked to the Environment: The WHOLE Approach to Personalized Medicine

    • Greg Gibson
    Pages 1-14

  3. Characterizing Multi-omic Data in Systems Biology

    • Christopher E. Mason, Sandra G. Porter, Todd M. Smith
    Pages 15-38

  4. High-Throughput Translational Medicine: Challenges and Solutions

    • Dinanath Sulakhe, Sandhya Balasubramanian, Bingqing Xie, Eduardo Berrocal, Bo Feng, Andrew Taylor et al.
    Pages 39-67

  5. Computational Approaches for Human Disease Gene Prediction and Ranking

    • Cheng Zhu, Chao Wu, Bruce J. Aronow, Anil G. Jegga
    Pages 69-84

  6. A Personalized Treatment for Lung Cancer: Molecular Pathways, Targeted Therapies, and Genomic Characterization

    • Thomas Hensing, Apoorva Chawla, Rishi Batra, Ravi Salgia
    Pages 85-117

  7. Back Matter

    Pages 119-122
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Editors and Affiliations

  • University of Chicago, Chicago, USA

    Natalia Maltsev, Andrey Rzhetsky, T. Conrad Gilliam

Bibliographic Information

  • Book Title: Systems Analysis of Human Multigene Disorders

  • Editors: Natalia Maltsev, Andrey Rzhetsky, T. Conrad Gilliam

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4614-8778-4

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2014

  • Hardcover ISBN: 978-1-4614-8777-7Published: 28 November 2013

  • Softcover ISBN: 978-1-4939-5194-9Published: 30 April 2017

  • eBook ISBN: 978-1-4614-8778-4Published: 29 November 2013

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XIII, 122

  • Number of Illustrations: 12 illustrations in colour

  • Topics: Systems Biology, Human Genetics

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