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  • Book
  • © 2013

Molecular Pathogenesis of Colorectal Cancer

Editors:

  1. Kevin M. Haigis, Ph.D.

    1. Molecular Pathology Unit, Harvard Medical School, Charlestown, USA

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  • Identification and characterization of targetable oncogenic pathways in colorectal cancer

  • Discussion of the current and future prospects for targeting that pathway therapeutically

  • Emerging technologies for identifying new cancer related genes, and therefore new therapeutic targets

  • Includes supplementary material: sn.pub/extras

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-viii
    PDF

  2. The Genetics of Colorectal Cancer

    • William Hankey, Joanna Groden
    Pages 1-24

  3. Molecular Mechanisms of Colorectal Carcinogenesis

    • Jatin Roper, Kenneth E. Hung
    Pages 25-65

  4. The Association Between Inflammation and Colorectal Cancer

    • Maria José Oliveira, Sérgia Velho
    Pages 67-105

  6. Mutational Activation of KRAS and BRAF in Colorectal Cancer

    • Katherine H. Pedone, Jennifer L. Sells, Channing J. Der
    Pages 121-156

  7. The PI3K Pathway in Colorectal Cancers

    • Jihye Yun, George Poulogiannis, Evan T. Brower, Samuel Klempner, Lewis L. Cantley
    Pages 157-199

  8. TGF-ß Signaling Pathway and Colorectal Cancer

    • William M. Grady
    Pages 201-230

  9. The Clinical Significance of Mutations in Colorectal Cancer

    • Franklin W. Huang, Laura B. Kleiman, Theodore S. Hong
    Pages 231-245

  10. Colorectal Cancer Genome and Its Implications

    • Nickolas Papadopoulos
    Pages 247-265

  11. Copy-Number Alterations in the Colorectal Cancer Genome

    • Jihun Kim, Adam J. Bass
    Pages 267-287

  14. Back Matter

    Pages 309-316
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About this book

Colorectal cancer has for more than two decades served as the paradigm for the multi-step concept of cancer initiation and progression. Perhaps more than any other organ site, cancer of the colon is extensively characterized at the molecular level. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with emerging targeted therapies. The book will focus on the progression from the identification of mutations that drive colorectal cancer initiation and progression to the search for novel therapies to treat the disease.
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Editors and Affiliations

  • Molecular Pathology Unit, Harvard Medical School, Charlestown, USA

    Kevin M. Haigis, Ph.D.

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Bibliographic Information

  • Book Title: Molecular Pathogenesis of Colorectal Cancer

  • Editors: Kevin M. Haigis, Ph.D.

  • DOI: https://doi.org/10.1007/978-1-4614-8412-7

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media New York 2013

  • Hardcover ISBN: 978-1-4614-8411-0Published: 03 October 2013

  • Softcover ISBN: 978-1-4939-4278-7Published: 23 August 2016

  • eBook ISBN: 978-1-4614-8412-7Published: 02 October 2013

  • Edition Number: 1

  • Number of Pages: VIII, 316

  • Number of Illustrations: 1 b/w illustrations, 29 illustrations in colour

  • Topics: Cancer Research, Molecular Medicine, Protein Science, Cell Biology

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Buy it now

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

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