Definition
Cross-platform software providing statistical analyses and plots of taxonomic and functional profiles.
Introduction
Comparative metagenomic studies aim to understand differences in the structure and function of microbial communities from different habitats. Statistical approaches can be used to highlight differences between pairs of metagenomic samples or defined groups of samples (e.g., samples from sick and healthy individuals). STAMP (Statistical Analysis of Metagenomic Profiles) is a software platform for analyzing metagenomic profiles (Parks and Beiko 2010), such as taxonomic profiles indicating the number of marker genes assigned to different taxonomic units or functional profiles indicating the number of sequences contributing to a specific subsystem or pathway. It aims to promote best practices in reporting statistical results by encouraging the use of effect sizes and confidence intervals when assessing biological importance. A user-friendly, graphical interface...
References
Arumugam M, Raes J, Pelletier E, et al. Enterotypes of the human gut microbiome. Nature. 2011;473:174–80.
Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc B. 1995;57:289–300.
Lingner T, Aßhauer KP, Schreiber F, Meinicke P. CoMet – a web server for comparative functional profiling of metagenomes. Nucleic Acids Res. 2011;39 Suppl 2:W518–23.
MacDonald NJ, Parks DH, Beiko RG. Rapid identification of high-confidence taxonomic assignments for metagenomic data. Nucleic Acids Res. 2012;40:e111.
Markowitz VM, Ivanona NN, Sveto E, et al. IMG/M: a data management and analysis system for metagenomes. Nucleic Acids Res. 2008;36(Database issue):D534–8.
Meyer F, Paarmann D, D’Souza M, et al. The metagenomics RAST server – a public resource for the automatic phylogenetic and functional analysis of metagenomes. BMC Bioinforma. 2008;9:386.
Parks DH, Beiko RG. Identifying biologically relevant differences between metagenomic communities. Bioinformatics. 2010;26:715–21.
Schloss PD, Westcott SL, Ryabin T, et al. Introducing mother: open-source, platform-independent, community-supported software for describing and comparing microbial communities. Appl Environ Microbiol. 2009;75:7537–41.
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Parks, D., Beiko, R. (2013). STAMP: Statistical Analysis of Metagenomic Profiles. In: Nelson, K. (eds) Encyclopedia of Metagenomics. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6418-1_780-1
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DOI: https://doi.org/10.1007/978-1-4614-6418-1_780-1
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Publisher Name: Springer, New York, NY
Online ISBN: 978-1-4614-6418-1
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