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Androgen-Responsive Genes in Prostate Cancer

Regulation, Function and Clinical Applications

  • Book
  • © 2013

Overview

Editors:
  1. Zhou Wang

    1. , Shadyside Medical Center, University of Pittsburgh, Pittsburgh, USA

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  • Focuses on androgen-responsive genes and prostate cancer, whereas other books have focused on androgen action and androgen receptors
  • Covers androgen-responsive genes in relation to carcinogenesis, cell growth, angiogenesis and more
  • Explores new approaches to diagnosis, prevention and treatment through understanding the mechanisms of androgen-responsive genes at the cellular level?
  • Includes supplementary material: sn.pub/extras

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About this book

Androgens and androgen receptors (AR) play critical roles in the development and progression of prostate cancer, the most frequently diagnosed cancer and second leading cause of cancer death in US males.  AR is an androgen-dependent DNA-binding transcription factor that regulates the expression of androgen-responsive genes.  Identification and characterization of androgen-responsive genes provide insights into the cellular mechanisms of androgen action and may lead to new approaches in diagnosis, prognosis, prevention and/or treatment of prostate cancer.   This volume provides critical information from  well respected experts in the field.  Some of the exciting topics include the new understanding of mechanisms underlining the regulation of androgen-responsive gene expression, and functions of various androgen-responsive genes in biological processes essential in carcinogenesis including cell growth, angiogenesis, and epithelial-to-mesenchyme transition (EMT).  Other important aspects addressed are the current and potential clinic applications of knowledge on androgen-responsive gene regulation and function.  This book is intended for researchers, scientists, faculty, and advanced graduate students  with an interest in androgen action and prostate cancer.​  

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-ix
    Download chapter PDF

  2. Roles of Androgen Receptor Coregulators and Cell Signaling in the Regulation of Androgen-Responsive Genes

    • Irina U. Agoulnik, Nancy L. Weigel
    Pages 1-11

  3. Selective and Classical Androgen Response Elements in Androgen-Regulated Gene Expression

    • Frank Claessens, Liesbeth Clinckemalie, Helsen Christine, Lien Spans, Vanessa Dubois, Michaël Laurent et al.
    Pages 13-27

  4. Negative Androgen-Response Elements in Androgen Target Genes

    • Wei Qi, Zhengxin Wang
    Pages 29-41

  5. Chromatin Looping and Long Distance Regulation by Androgen Receptor

    • Benjamin Sunkel, Qianben Wang
    Pages 43-58

  6. The Functionality of Prostate Cancer Predisposition Risk Regions Is Revealed by AR Enhancers

    • Houtan Noushmehr, Simon G. Coetzee, Suhn K. Rhie, Chunli Yan, Gerhard A. Coetzee
    Pages 59-84

  7. Mechanisms of ARE-Independent Gene Activation by the Androgen Receptor in Prostate Cancer Cells: Potential Targets for Better Intervention Strategies

    • Manohar Ratnam, Mugdha Patki, Mesfin Gonit, Robert Trumbly
    Pages 85-100

  8. Androgen Action, Wnt Signaling, and Prostate Tumorigenesis

    • Zijie Sun, Suk Hyung Lee
    Pages 101-116

  9. Toward Revealing the Complexity of Androgen-Responsive Protein and Noncoding Transcripts in Prostate Cancer

    • Melanie L. Lehman, Colleen C. Nelson
    Pages 117-134

  10. Androgen-Responsive Gene Expression in Prostate Cancer Progression

    • Amy H. Tien, Marianne D. Sadar
    Pages 135-153

  11. Androgen Receptor-Regulated Genes in Prostate Cancer Initiation Versus Metastasis

    • Soo Ok Lee, Chiung-Kuei Huang, Luo Jie, Chawnshang Chang
    Pages 155-176

  12. Androgen-Independent Induction of Androgen-Responsive Genes by Interleukin-6 Regulation

    • Zoran Culig
    Pages 177-185

  13. The Effect of AR Overexpression on Androgen Signaling in Prostate Cancer

    • Alfonso Urbanucci, Kati K. Waltering, Ian G. Mills, Tapio Visakorpi
    Pages 187-200

  14. The Expression Signature of Androgen Receptor Splice Variants and Their Distinctive Transcriptional Activities in Castration-Resistant Prostate Cancer

    • Stephen R. Plymate, Jun Luo
    Pages 201-213

  15. Androgen Regulation of the Cell Cycle in Prostate Cancer

    • Haojie Huang
    Pages 215-225

  16. Androgen Receptor Signaling Interactions Control Epithelial–Mesenchymal Transition (EMT) in Prostate Cancer Progression

    • Sarah K. Martin, Michael V. Fiandalo, Natasha Kyprianou
    Pages 227-255

  17. Androgen Receptor Regulation of Serum Response Factor Signaling in Prostate Cancer

    • Alissa R. Verone, Hannelore V. Heemers
    Pages 257-271

  18. Regulation of Angiogenesis by Androgen-Responsive Gene EAF2

    • Laura E. Pascal, Zhou Wang
    Pages 273-283

  19. The Role of miR-21, an Androgen-Regulated MicroRNA, in Prostate Cancer

    • Judit Ribas, Shawn E. Lupold
    Pages 285-305

  20. Androgen-Dependent Oncogenic Activation of ETS Transcription Factors by Recurrent Gene Fusions in Prostate Cancer: Biological and Clinical Implications

    • Albert Dobi, Taduru Sreenath, Shiv Srivastava
    Pages 307-328
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Editors and Affiliations

  • , Shadyside Medical Center, University of Pittsburgh, Pittsburgh, USA

    Zhou Wang

About the editor

The volume editor, Dr. Zhou Wang, is well-noted in the field of prostate cancer and he is theChair for Urological Research at the University of Pittsburgh Medical Center, as well as the co-director of Urological and Prostate Cancer Program at the University of Pittsburgh Cancer Institute.He has also conducted several scientific reviews for several top journals in the area of cancer research.

Bibliographic Information

  • Book Title: Androgen-Responsive Genes in Prostate Cancer

  • Book Subtitle: Regulation, Function and Clinical Applications

  • Editors: Zhou Wang

  • DOI: https://doi.org/10.1007/978-1-4614-6182-1

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media, LLC 2013

  • Hardcover ISBN: 978-1-4614-6181-4Published: 16 February 2013

  • Softcover ISBN: 978-1-4899-8687-0Published: 08 February 2015

  • eBook ISBN: 978-1-4614-6182-1Published: 16 February 2013

  • Edition Number: 1

  • Number of Pages: IX, 348

  • Number of Illustrations: 38 b/w illustrations, 37 illustrations in colour

  • Topics: Cancer Research, Gene Therapy, Human Genetics

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