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Tumor Microenvironment and Cellular Stress

Signaling, Metabolism, Imaging, and Therapeutic Targets

  • Conference proceedings
  • © 2014

Overview

Editors:
  1. Constantinos Koumenis

    1. Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA

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  2. Ester Hammond

    1. Cancer Research, Gray Institute for Radiation Oncology, Oxford, United Kingdom

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  3. Amato Giaccia

    1. Department of Radiation Oncology, Stanford University School of Medicine, Stanford, USA

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  • Explores significant advances in understanding the genetic determinants of stress responses?
  • Discusses various cellular and animal models of tumor microenvironment study
  • Features novel targets for imaging and therapeutic intervention

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 772)

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About this book

The collection of chapters in this proceeding volume reflects the latest research presented at the Aegean meeting on Tumor Microenvironment and Cellular Stress held in Crete in Fall of 2012. The book provides critical insight to how the tumor microenvironment affects tumor metabolism, cell stemness, cell viability, genomic instability and more. Additional topics include identifying common pathways that are potential candidates for therapeutic intervention, which will stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery.

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Table of contents (12 papers)

  1. Front Matter

    Pages i-x
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  2. Hypoxia and Metabolism in Cancer

    • Karim Bensaad, Adrian L. Harris
    Pages 1-39

  3. Hypoxia and Regulation of Cancer Cell Stemness

    • Zhong Yun, Qun Lin
    Pages 41-53

  4. Hypoxia-Mediated Metastasis

    • Joan Chang, Janine Erler
    Pages 55-81

  5. Escape Mechanisms from Antiangiogenic Therapy: An Immune Cell’s Perspective

    • Lee Rivera, Melissa Pandika, Gabriele Bergers
    Pages 83-99

  6. Hypoxic VDAC1: A Potential Mitochondrial Marker for Cancer Therapy

    • M. Christiane Brahimi-Horn, N. M. Mazure
    Pages 101-110

  7. Hypoxia-Directed Drug Strategies to Target the Tumor Microenvironment

    • Michael P. Hay, Kevin O. Hicks, Jingli Wang
    Pages 111-145

  8. Radiotherapy and the Tumor Microenvironment: Mutual Influence and Clinical Implications

    • Reid F. Thompson, Amit Maity
    Pages 147-165

  9. Autophagy and Cell Death to Target Cancer Cells: Exploiting Synthetic Lethality as Cancer Therapies

    • Julie Reyjal, Kevin Cormier, Sandra Turcotte
    Pages 167-188

  10. Intratumoral Hypoxia as the Genesis of Genetic Instability and Clinical Prognosis in Prostate Cancer

    • Daria Taiakina, Alan Dal Pra, Robert G. Bristow
    Pages 189-204

  11. miR-210: Fine-Tuning the Hypoxic Response

    • Mircea Ivan, Xin Huang
    Pages 205-227

  12. The Role of Complement in Tumor Growth

    • Ruben Pio, Leticia Corrales, John D. Lambris
    Pages 229-262

  13. Imaging Angiogenesis, Inflammation, and Metastasis in the Tumor Microenvironment with Magnetic Resonance Imaging

    • Sébastien Serres, Emma R. O’Brien, Nicola R. Sibson
    Pages 263-283

  14. Back Matter

    Pages 285-290
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Editors and Affiliations

  • Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA

    Constantinos Koumenis

  • Cancer Research, Gray Institute for Radiation Oncology, Oxford, United Kingdom

    Ester Hammond

  • Department of Radiation Oncology, Stanford University School of Medicine, Stanford, USA

    Amato Giaccia

About the editors

Constantinos Koumenis, Ph.D. is an Associate Professor, Vice Chair and Research Division Director and Co-Leader, Radiation Biology & Imaging Program at the University of Pennsylvania, School of Medicine. Amato Giacca,Ph.D., is a Professor and Director of the Department of Radiation Oncology, Leader of Radation Biology and Molecular Therapeutics Program at the Stanford Cancer Center. Ester Hammond Ph.D., is a Junior Group Leader at Gray Institute for Radiation Oncology and Biology at Oxford University.

Bibliographic Information

  • Book Title: Tumor Microenvironment and Cellular Stress

  • Book Subtitle: Signaling, Metabolism, Imaging, and Therapeutic Targets

  • Editors: Constantinos Koumenis, Ester Hammond, Amato Giaccia

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4614-5915-6

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2014

  • Hardcover ISBN: 978-1-4614-5914-9Published: 24 November 2013

  • Softcover ISBN: 978-1-4939-4705-8Published: 23 August 2016

  • eBook ISBN: 978-1-4614-5915-6Published: 23 November 2013

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: X, 290

  • Number of Illustrations: 8 b/w illustrations, 30 illustrations in colour

  • Topics: Cancer Research, Immunology, Human Physiology, Medical Microbiology

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