Skip to main content
SpringerLink
Log in

Ablation and Cementation Technologies

  • Chapter
Metastatic Bone Disease

  • 1326 Accesses

Abstract

Metastatic bone tumors can replace and compress normal healthy tissue, causing structural instability, elicit pain, and cause fractures which often require treatment. Treatment has historically focused on radiation, medical, and surgical options with interventional therapies providing a limited role. Interventional therapies, however, continue to evolve providing additional treatment options such as vertebroplasty, kyphoplasty, radiofrequency ablation, and cryoablation for metastatic bone malignancies, particularly for treatment of spinal tumors and their associated pathologies. These interventional therapies can provide alternate or complimentary therapies for patients in the appropriate clinical setting. This chapter provides an overview of these interventional treatment options and discusses some of the more recent developments in this rapidly growing field.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 139.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

FDA:

Food and Drug Administration

IMRT:

Intensity modulated radiation therapy

KP:

Kyphoplasty

PMMA:

Polymethylmethacrylate

SBRT:

Stereotactic body radiation therapy

VAS:

Visual analog scale

VAT:

Vertebral augmentation therapy

VCF:

Vertebral compression fractures

VP:

Vertebroplasty

References

  1. Nielsen OS, Munro AJ, Tannock IF. Bone metastases: pathophysiology and management policy. J Clin Oncol. 1991;9(3):509–24.

    CAS  PubMed  Google Scholar 

  2. Dupuy DE, Liu D, Hartfeil D, Hanna L, Blume JD, Ahrar K, et al. Percutaneous radiofrequency ablation of painful osseous metastases: a Multi-Center American College of Radiology Imaging Network trial. Cancer. 2010;116(4):989–97.

    Article  PubMed Central  PubMed  Google Scholar 

  3. Dudeney S, Lieberman IH, Reinhardt MK, Hussein M. Kyphoplasty in the treatment of osteolytic vertebral compression fractures as a result of multiple myeloma. J Clin Oncol. 2002;20(9):2382–7.

    Article  CAS  PubMed  Google Scholar 

  4. Jensen ME, Kallmes DE. Percutaneous vertebroplasty in the treatment of malignant spine disease. Cancer J. 2002;8(2):194–206.

    Article  PubMed  Google Scholar 

  5. Fourney DR, Schomer DF, Nader R, Chlan-Fourney J, Suki D, Ahrar K, et al. Percutaneous vertebroplasty and kyphoplasty for painful vertebral body fractures in cancer patients. J Neurosurg. 2003;98(1 Suppl):21–30.

    PubMed  Google Scholar 

  6. Lane JM, Hong R, Koob J, Kiechle T, Niesvizky R, Pearse R, et al. Kyphoplasty enhances function and structural alignment in multiple myeloma. Clin Orthop Relat Res. 2004;426:49–53.

    Article  PubMed  Google Scholar 

  7. Burton AW, Reddy SK, Shah HN, Tremont-Lukats I, Mendel E. Percutaneous vertebroplasty--a technique to treat refractory spinal pain in the setting of advanced metastatic cancer: a case series. J Pain Symptom Manage. 2005;30(1):87–95.

    Article  PubMed  Google Scholar 

  8. Burton AW, Rhines LD, Mendel E. Vertebroplasty and kyphoplasty: a comprehensive review. Neurosurg Focus. 2005;18(3):e1.

    Article  PubMed  Google Scholar 

  9. Gaitanis IN, Hadjipavlou AG, Katonis PG, Tzermiadianos MN, Pasku DS, Patwardhan AG. Balloon kyphoplasty for the treatment of pathological vertebral compressive fractures. Eur Spine J. 2005;14(3):250–60.

    Article  PubMed Central  PubMed  Google Scholar 

  10. Gerszten PC, Germanwala A, Burton SA, Welch WC, Ozhasoglu C, Vogel WJ. Combination kyphoplasty and spinal radiosurgery: a new treatment paradigm for pathological fractures. J Neurosurg Spine. 2005;3(4):296–301.

    Article  PubMed  Google Scholar 

  11. Hentschel SJ, Burton AW, Fourney DR, Rhines LD, Mendel E. Percutaneous vertebroplasty and kyphoplasty performed at a cancer center: refuting proposed contraindications. J Neurosurg Spine. 2005;2(4):436–40.

    Article  PubMed  Google Scholar 

  12. Kose KC, Cebesoy O, Akan B, Altinel L, Dincer D, Yazar T. Functional results of vertebral augmentation techniques in pathological vertebral fractures of myelomatous patients. J Natl Med Assoc. 2006;98(10):1654–8.

    PubMed Central  PubMed  Google Scholar 

  13. Calmels V, Vallee JN, Rose M, Chiras J. Osteoblastic and mixed spinal metastases: evaluation of the analgesic efficacy of percutaneous vertebroplasty. AJNR Am J Neuroradiol. 2007;28(3):570–4.

    CAS  PubMed  Google Scholar 

  14. Georgy BA. Metastatic spinal lesions: state-of-the-art treatment options and future trends. AJNR Am J Neuroradiol. 2008;29(9):1605–11.

    Article  CAS  PubMed  Google Scholar 

  15. Hussein MA, Vrionis FD, Allison R, Berenson J, Berven S, Erdem E, et al. The role of vertebral augmentation in multiple myeloma: International Myeloma Working Group Consensus Statement. Leukemia. 2008;22:1479–84.

    Article  CAS  PubMed  Google Scholar 

  16. Oakland RJ, Furtado NR, Timothy J, Hall RM. The biomechanics of vertebroplasty in multiple myeloma and metastatic bladder cancer: a preliminary cadaveric investigation. J Neurosurg Spine. 2008;9(5):493–501.

    Article  PubMed  Google Scholar 

  17. Burton AW, Mendoza T, Gebhardt R, Hamid B, Nouri K, Perez-Toro M, et al. Vertebral compression fracture treatment with vertebroplasty and kyphoplasty: experience in 407 patients with 1,156 fractures in a tertiary cancer center. Pain Med. 2011;12(12):1750–7.

    Article  PubMed  Google Scholar 

  18. Eleraky M, Papanastassiou I, Setzer M, Baaj AA, Tran ND, Vrionis FD. Balloon kyphoplasty in the treatment of metastatic tumors of the upper thoracic spine. J Neurosurg Spine. 2011;14(3):372–6.

    Article  PubMed  Google Scholar 

  19. Kasperk C, Haas A, Hillengass J, Weiss C, Neben K, Goldschmidt H, et al. Kyphoplasty in patients with multiple myeloma a retrospective comparative pilot study. J Surg Oncol. 2012;105(7):679–86.

    Article  PubMed  Google Scholar 

  20. Konig MA, Jehan S, Balamurali G, Bierschneider M, Grillhosl A, Boszczyk BM. Kyphoplasty for lytic tumour lesions of the spine: prospective follow-up of 11 cases from procedure to death. Eur Spine J. 2012;21(9):1873–9.

    Article  PubMed Central  PubMed  Google Scholar 

  21. Erdem E, Akdol S, Amole A, Fryar K, Eberle RW. Radiofrequency-targeted vertebral augmentation for the treatment of vertebral compression fractures as a result of multiple myeloma. Spine. 2013;38(15):1275–81.

    Article  PubMed  Google Scholar 

  22. Kado DM, Browner WS, Palermo L, Nevitt MC, Genant HK, Cummings SR. Vertebral fractures and mortality in older women: a prospective study. Study of Osteoporotic Fractures Research Group. Arch Intern Med. 1999;159(11):1215–20.

    Article  CAS  PubMed  Google Scholar 

  23. Delworth MG, Pisters LL, Fornage BD, von Eschenbach AC. Cryotherapy for renal cell carcinoma and angiomyolipoma. J Urol. 1996;155(1):252–4. discussion 4-5.

    Article  CAS  PubMed  Google Scholar 

  24. Bilchik AJ, Wood TF, Allegra D, Tsioulias GJ, Chung M, Rose DM, et al. Cryosurgical ablation and radiofrequency ablation for unresectable hepatic malignant neoplasms: a proposed algorithm. Arch Surg. 2000;135(6):657–62. discussion 62–4.

    Article  CAS  PubMed  Google Scholar 

  25. Gazelle GS, Goldberg SN, Solbiati L, Livraghi T. Tumor ablation with radio-frequency energy. Radiology. 2000;217(3):633–46.

    Article  CAS  PubMed  Google Scholar 

  26. Dupuy DE, Goldberg SN. Image-guided radiofrequency tumor ablation: challenges and opportunities--part II. J Vasc Interv Radiol. 2001;12(10):1135–48.

    Article  CAS  PubMed  Google Scholar 

  27. Gervais DA, McGovern FJ, Arellano RS, McDougal WS, Mueller PR. Renal cell carcinoma: clinical experience and technical success with radio-frequency ablation of 42 tumors. Radiology. 2003;226(2):417–24.

    Article  PubMed  Google Scholar 

  28. Mayo-Smith WW, Dupuy DE, Parikh PM, Pezzullo JA, Cronan JJ. Imaging-guided percutaneous radiofrequency ablation of solid renal masses: techniques and outcomes of 38 treatment sessions in 32 consecutive patients. AJR Am J Roentgenol. 2003;180(6):1503–8.

    Article  PubMed  Google Scholar 

  29. Hafron J, Kaouk JH. Cryosurgical ablation of renal cell carcinoma. Cancer Control. 2007;14(3):211–7.

    PubMed  Google Scholar 

  30. Littrup PJ, Ahmed A, Aoun HD, Noujaim DL, Harb T, Nakat S, et al. CT-guided percutaneous cryotherapy of renal masses. J Vasc Interv Radiol. 2007;18(3):383–92.

    Article  PubMed  Google Scholar 

  31. Zagoria RJ, Traver MA, Werle DM, Perini M, Hayasaka S, Clark PE. Oncologic efficacy of CT-guided percutaneous radiofrequency ablation of renal cell carcinomas. AJR Am J Roentgenol. 2007;189(2):429–36.

    Article  PubMed  Google Scholar 

  32. Uppot RN, Silverman SG, Zagoria RJ, Tuncali K, Childs DD, Gervais DA. Imaging-guided percutaneous ablation of renal cell carcinoma: a primer of how we do it. AJR Am J Roentgenol. 2009;192(6):1558–70.

    Article  PubMed  Google Scholar 

  33. Gervais DA, Arellano RS. Percutaneous tumor ablation for hepatocellular carcinoma. AJR Am J Roentgenol. 2011;197(4):789–94.

    Article  PubMed  Google Scholar 

  34. Welch BT, Atwell TD, Nichols DA, Wass CT, Callstrom MR, Leibovich BC, et al. Percutaneous image-guided adrenal cryoablation: procedural considerations and technical success. Radiology. 2011;258(1):301–7.

    Article  PubMed  Google Scholar 

  35. Goetz MP, Callstrom MR, Charboneau JW, Farrell MA, Maus TP, Welch TJ, et al. Percutaneous image-guided radiofrequency ablation of painful metastases involving bone: a multicenter study. J Clin Oncol. 2004;22:300.

    Article  PubMed  Google Scholar 

  36. Di Staso M, Zugaro L, Gravina GL, Bonfili P, Marampon F, Di Nicola L, et al. A feasibility study of percutaneous Radiofrequency Ablation followed by Radiotherapy in the management of painful osteolytic bone metastases. Eur Radiol. 2011;21(9):2004–10.

    Article  PubMed  Google Scholar 

  37. Lane MD, Le HB, Lee S, Young C, Heran MK, Badii M, et al. Combination radiofrequency ablation and cementoplasty for palliative treatment of painful neoplastic bone metastasis: experience with 53 treated lesions in 36 patients. Skeletal Radiol. 2011;40(1):25–32.

    Article  PubMed  Google Scholar 

  38. Jennings J, Irving W, Georgy B, Coldwell D, Zablow B, DePena C, et al. Image-guided targeted radiofrequency ablation (t-RFA) of spinal tumors using a novel bipolar navigational device: multicenter initial clinical experience. J Vasc Interv Radiol. 2013;24(4):S44.

    Article  Google Scholar 

  39. Mercadante S. Malignant bone pain: pathophysiology and treatment. Pain. 1997;69(1-2):1–18.

    Article  CAS  PubMed  Google Scholar 

  40. Rose PS, Laufer I, Boland PJ, Hanover A, Bilsky MH, Yamada J, et al. Risk of fracture after single fraction image-guided intensity-modulated radiation therapy to spinal metastases. J Clin Oncol. 2009;27(30):5075–9.

    Article  PubMed Central  PubMed  Google Scholar 

  41. Twycross RG. Management of pain in skeletal metastases. Clin Orthop Relat Res. 1995;312:187–96.

    PubMed  Google Scholar 

  42. Bailey JF, Liebenberg E, Degmetich S, Lotz JC. Innervation patterns of PGP 9.5-positive nerve fibers within the human lumbar vertebra. J Anat. 2011;218(3):263–70.

    Article  PubMed Central  PubMed  Google Scholar 

  43. Grönblad M, Liesi P, Korkala O, et al. Innervation of human bone periosteum by peptidergic nerves. Anat Rec. 2014;209(3):297–9.

    Article  Google Scholar 

  44. Ryu S, Rock J, Rosenblum M, Kim JH. Patterns of failure after single-dose radiosurgery for spinal metastasis. J Neurosurg. 2004;101 Suppl 3:402–5.

    PubMed  Google Scholar 

  45. Chang EL, Shiu AS, Mendel E, Mathews LA, Mahajan A, Allen PK, et al. Phase I/II study of stereotactic body radiotherapy for spinal metastasis and its pattern of failure. J Neurosurg Spine. 2007;7(2):151–60.

    Article  PubMed  Google Scholar 

  46. Gerszten PC, Burton SA, Ozhasoglu C, Welch WC. Radiosurgery for spinal metastases: clinical experience in 500 cases from a single institution. Spine. 2007;32(2):193–9.

    Article  PubMed  Google Scholar 

  47. Gibbs IC, Kamnerdsupaphon P, Ryu MR, Dodd R, Kiernan M, Chang SD, et al. Image-guided robotic radiosurgery for spinal metastases. Radiother Oncol. 2007;82(2):185–90.

    Article  PubMed  Google Scholar 

  48. Jin JY, Chen Q, Jin R, Rock J, Anderson J, Li S, et al. Technical and clinical experience with spine radiosurgery: a new technology for management of localized spine metastases. Technol Cancer Res Treat. 2007;6(2):127–33.

    Article  PubMed  Google Scholar 

  49. Ryu S, Jin JY, Jin R, Rock J, Ajlouni M, Movsas B, et al. Partial volume tolerance of the spinal cord and complications of single-dose radiosurgery. Cancer. 2007;109(3):628–36.

    Article  PubMed  Google Scholar 

  50. Yamada Y, Bilsky MH, Lovelock DM, Venkatraman ES, Toner S, Johnson J, et al. High-dose, single-fraction image-guided intensity-modulated radiotherapy for metastatic spinal lesions. Int J Radiat Oncol Biol Phys. 2008;71(2):484–90.

    Article  PubMed  Google Scholar 

  51. Gagnon GJ, Nasr NM, Liao JJ, Molzahn I, Marsh D, McRae D, et al. Treatment of spinal tumors using cyberknife fractionated stereotactic radiosurgery: pain and quality-of-life assessment after treatment in 200 patients. Neurosurgery. 2009;64(2):297–306. discussion 7.

    Article  PubMed  Google Scholar 

  52. Sheehan JP, Shaffrey CI, Schlesinger D, Williams BJ, Arlet V, Larner J. Radiosurgery in the treatment of spinal metastases: tumor control, survival, and quality of life after helical tomotherapy. Neurosurgery. 2009;65(6):1052–61. discussion 61-2.

    Article  PubMed  Google Scholar 

  53. Tsai JT, Lin JW, Chiu WT, Chu WC. Assessment of image-guided CyberKnife radiosurgery for metastatic spine tumors. J Neurooncol. 2009;94(1):119–27.

    Article  PubMed  Google Scholar 

  54. Boehling NS, Grosshans DR, Allen PK, McAleer MF, Burton AW, Azeem S, et al. Vertebral compression fracture risk after stereotactic body radiotherapy for spinal metastases. J Neurosurg Spine. 2012;16(4):379–86.

    Article  PubMed  Google Scholar 

  55. Taneichi H, Kaneda K, Takeda N, Abumi K, Satoh S. Risk factors and probability of vertebral body collapse in metastases of the thoracic and lumbar spine. Spine. 1997;22(3):239–45.

    Article  CAS  PubMed  Google Scholar 

  56. Shah AN, Pietrobon R, Richardson WJ, Myers BS. Patterns of tumor spread and risk of fracture and epidural impingement in metastatic vertebrae. J Spinal Disord Tech. 2003;16(1):83–9.

    Article  PubMed  Google Scholar 

  57. Proschek D, Kurth A, Proschek P, Vogl TJ, Mack MG. Prospective pilot-study of combined bipolar radiofrequency ablation and application of bone cement in bone metastases. Anticancer Res. 2009;29(7):2787–92.

    PubMed  Google Scholar 

  58. Buckwalter JA, Brandser EA. Metastatic disease of the skeleton. Am Fam Physician. 1997;55(5):1761–8.

    CAS  PubMed  Google Scholar 

  59. Coleman RE. Skeletal complications of malignancy. Cancer. 1997;80(8 Suppl):1588–94.

    Article  CAS  PubMed  Google Scholar 

  60. Eleraky M, Papanastassiou I, Vrionis FD. Management of metastatic spine disease. Curr Opin Support Palliat Care. 2010;4(3):182–8.

    Article  PubMed  Google Scholar 

  61. Papanastassiou ID, Aghayev K, Saleh E, Gerochristou M, Vrionis FD. The actual management of tumor and vertebral compression fractures. J Neurosurg Sci. 2012;56(2):77–85.

    CAS  PubMed  Google Scholar 

  62. Buchbinder R, Osborne RH, Ebeling PR, Wark JD, Mitchell P, Wriedt C, et al. A randomized trial of vertebroplasty for painful osteoporotic vertebral fractures. N Engl J Med. 2009;361(6):557–68.

    Article  CAS  PubMed  Google Scholar 

  63. Kallmes DF, Comstock BA, Heagerty PJ, Turner JA, Wilson DJ, Diamond TH, et al. A randomized trial of vertebroplasty for osteoporotic spinal fractures. N Engl J Med. 2009;361(6):569–79.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  64. Voormolen MH, Mali WP, Lohle PN, Fransen H, Lampmann LE, van der Graaf Y, et al. Percutaneous vertebroplasty compared with optimal pain medication treatment: short-term clinical outcome of patients with subacute or chronic painful osteoporotic vertebral compression fractures. The VERTOS study. AJNR Am J Neuroradiol. 2007;28(3):555–60.

    CAS  PubMed  Google Scholar 

  65. Wardlaw D, Cummings SR, Van Meirhaeghe J, Bastian L, Tillman JB, Ranstam J, et al. Efficacy and safety of balloon kyphoplasty compared with non-surgical care for vertebral compression fracture (FREE): a randomised controlled trial. Lancet. 2009;373(9668):1016–24.

    Article  PubMed  Google Scholar 

  66. Klazen CA, Lohle PN, de Vries J, Jansen FH, Tielbeek AV, Blonk MC, et al. Vertebroplasty versus conservative treatment in acute osteoporotic vertebral compression fractures (Vertos II): an open-label randomised trial. Lancet. 2010;376(9746):1085–92.

    Article  PubMed  Google Scholar 

  67. Berenson J, Pflugmacher R, Jarzem P, Zonder J, Schechtman K, Tillman JB, et al. Balloon kyphoplasty versus non-surgical fracture management for treatment of painful vertebral body compression fractures in patients with cancer: a multicentre, randomised controlled trial. Lancet Oncol. 2011;12(3):225–35.

    Article  PubMed  Google Scholar 

  68. Voormolen MH, van Rooij WJ, van der Graaf Y, Lohle PN, Lampmann LE, Juttmann JR, et al. Bone marrow edema in osteoporotic vertebral compression fractures after percutaneous vertebroplasty and relation with clinical outcome. AJNR Am J Neuroradiol. 2006;27(5):983–8.

    CAS  PubMed  Google Scholar 

  69. Brown DB, Gilula LA, Sehgal M, Shimony JS. Treatment of chronic symptomatic vertebral compression fractures with percutaneous vertebroplasty. AJR Am J Roentgenol. 2004;182(2):319–22.

    Article  PubMed  Google Scholar 

  70. Tomita K, Kawahara N, Kobayashi T, Yoshida A, Murakami H, Akamaru T. Surgical strategy for spinal metastases. Spine. 2001;26(3):298–306.

    Article  CAS  PubMed  Google Scholar 

  71. Tokuhashi Y, Matsuzaki H, Oda H, Oshima M, Ryu J. A revised scoring system for preoperative evaluation of metastatic spine tumor prognosis. Spine. 2005;30(19):2186–91.

    Article  PubMed  Google Scholar 

  72. White BD, Stirling AJ, Paterson E, Asquith-Coe K, Melder A. Diagnosis and management of patients at risk of or with metastatic spinal cord compression: summary of NICE guidance. BMJ. 2008;337:a2538.

    Article  CAS  PubMed  Google Scholar 

  73. Stoffel M, Wolf I, Ringel F, Stuer C, Urbach H, Meyer B. Treatment of painful osteoporotic compression and burst fractures using kyphoplasty: a prospective observational design. J Neurosurg Spine. 2007;6(4):313–9.

    Article  PubMed  Google Scholar 

  74. Pan J, Qian ZL, Sun ZY, Yang HL. Open kyphoplasty in the treatment of a painful vertebral lytic lesion with spinal cord compression caused by multiple myeloma: a case report. Oncol Lett. 2013;5(5):1621–4.

    PubMed Central  PubMed  Google Scholar 

  75. Papanastassiou ID, Filis A, Gerochristou MA, Vrionis FD. Controversial issues in kyphoplasty and vertebroplasty in osteoporotic vertebral fractures. Biomed Res Int. 2014;2014:934206.

    PubMed Central  PubMed  Google Scholar 

  76. Papanastassiou ID, Phillips FM, Van Meirhaeghe J, Berenson JR, Andersson GB, Chung G, et al. Comparing effects of kyphoplasty, vertebroplasty, and non-surgical management in a systematic review of randomized and non-randomized controlled studies. Eur Spine J. 2012;21(9):1826–43.

    Article  PubMed Central  PubMed  Google Scholar 

  77. Glassman SD, Bridwell K, Dimar JR, Horton W, Berven S, Schwab F. The impact of positive sagittal balance in adult spinal deformity. Spine. 2005;30(18):2024–9.

    Article  PubMed  Google Scholar 

  78. Aghayev K, Papanastassiou ID, Vrionis F. Role of vertebral augmentation procedures in the management of vertebral compression fractures in cancer patients. Curr Opin Support Palliat Care. 2011;5(3):222–6.

    Article  PubMed  Google Scholar 

  79. Liu FJ, Ren H, Shen Y, Ding WY, Wang LF. Pulmonary embolism caused by cement leakage after percutaneous kyphoplasty: a case report. Orthop Surg. 2012;4(4):263–5.

    Article  PubMed  Google Scholar 

  80. Llanos RA, Viana-Tejedor A, Abella HR, Fernandez-Aviles F. Pulmonary and intracardiac cement embolism after a percutaneous vertebroplasty. Clin Res Cardiol. 2013;102(5):395–7.

    Article  PubMed  Google Scholar 

  81. Krishnan EC, Nelson C, Neff JR. Thermodynamic considerations of acrylic cement implant at the site of giant cell tumors of the bone. Med Phys. 1986;13(2):233–9.

    Article  CAS  PubMed  Google Scholar 

  82. Deramond H, Wright NT, Belkoff SM. Temperature elevation caused by bone cement polymerization during vertebroplasty. Bone. 1999;25(2 Suppl):17s–21.

    Article  CAS  PubMed  Google Scholar 

  83. Belkoff SM, Molloy S. Temperature measurement during polymerization of polymethylmethacrylate cement used for vertebroplasty. Spine. 2003;28(14):1555–9.

    PubMed  Google Scholar 

  84. Lai PL, Chen LH, Chen WJ, Chu IM. Chemical and physical properties of bone cement for vertebroplasty. Biomed J. 2013;36(4):162–7.

    Article  PubMed  Google Scholar 

  85. Togawa D, Kovacic JJ, Bauer TW, Reinhardt MK, Brodke DS, Lieberman IH. Radiographic and histologic findings of vertebral augmentation using polymethylmethacrylate in the primate spine: percutaneous vertebroplasty versus kyphoplasty. Spine. 2006;31(1):E4–10.

    Article  PubMed  Google Scholar 

  86. Grafe IA, Baier M, Noldge G, Weiss C, Da Fonseca K, Hillmeier J, et al. Calcium-phosphate and polymethylmethacrylate cement in long-term outcome after kyphoplasty of painful osteoporotic vertebral fractures. Spine. 2008;33(11):1284–90.

    Article  PubMed  Google Scholar 

  87. Urrutia J, Bono CM, Mery P, Rojas C. Early histologic changes following polymethylmethacrylate injection (vertebroplasty) in rabbit lumbar vertebrae. Spine. 2008;33(8):877–82.

    Article  PubMed  Google Scholar 

  88. Liebschner MA, Rosenberg WS, Keaveny TM. Effects of bone cement volume and distribution on vertebral stiffness after vertebroplasty. Spine. 2001;26(14):1547–54.

    Article  CAS  PubMed  Google Scholar 

  89. Kruger A, Baroud G, Noriega D, Figiel J, Dorschel C, Ruchholtz S, et al. Height restoration and maintenance after treating unstable osteoporotic vertebral compression fractures by cement augmentation is dependent on the cement volume used. Clin Biomech. 2013;28(7):725–30.

    Article  Google Scholar 

  90. Xu C, Liu HX, Xu HZ. Analysis of related factors on the deformity correction of balloon kyphoplasty. AJNR Am J Neuroradiol. 2014;35(1):202–6.

    Article  CAS  PubMed  Google Scholar 

  91. Roder C, Boszczyk B, Perler G, Aghayev E, Kulling F, Maestretti G. Cement volume is the most important modifiable predictor for pain relief in BKP: results from SWISSspine, a nationwide registry. Eur Spine J. 2013;22(10):2241–8.

    Article  PubMed Central  PubMed  Google Scholar 

  92. Papanastassiou ID, Aghayev K, Berenson JR, Schmidt MH, Vrionis FD. Is vertebral augmentation the right choice for cancer patients with painful vertebral compression fractures? J Natl Compr Canc Netw. 2012;10(6):715–9.

    PubMed  Google Scholar 

  93. Katonis P, Pasku D, Alpantaki K, Bano A, Tzanakakis G, Karantanas A. Treatment of pathologic spinal fractures with combined radiofrequency ablation and balloon kyphoplasty. World J Surg Oncol. 2009;7:90.

    Article  PubMed Central  PubMed  Google Scholar 

  94. Lim CT, Tan LB, Nathan SS. Prospective evaluation of argon gas probe delivery for cryotherapy of bone tumours. Ann Acad Med Singapore. 2012;41(8):347–53.

    PubMed  Google Scholar 

  95. Rosenthal DI, Hornicek FJ, Wolfe MW, Jennings LC, Gebhardt MC, Mankin HJ. Percutaneous radiofrequency coagulation of osteoid osteoma compared with operative treatment. J Bone Joint Surg Am. 1998;80(6):815–21.

    CAS  PubMed  Google Scholar 

  96. Martel J, Bueno A, Ortiz E. Percutaneous radiofrequency treatment of osteoid osteoma using cool-tip electrodes. Eur J Radiol. 2005;56(3):403–8.

    Article  PubMed  Google Scholar 

  97. Hoffmann RT, Jakobs TF, Kubisch CH, Trumm CG, Weber C, Duerr HR, et al. Radiofrequency ablation in the treatment of osteoid osteoma-5-year experience. Eur J Radiol. 2010;73(2):374–9.

    Article  PubMed  Google Scholar 

  98. Rehnitz C, Sprengel SD, Lehner B, Ludwig K, Omlor G, Merle C, et al. CT-guided radiofrequency ablation of osteoid osteoma and osteoblastoma: clinical success and long-term follow up in 77 patients. Eur J Radiol. 2012;81(11):3426–34.

    Article  PubMed  Google Scholar 

  99. de Palma L, Candelari R, Antico E, Politano R, Luniew E, Giordanengo M, et al. Treatment of osteoid osteoma with CT-guided percutaneous radiofrequency thermoablation. Orthopedics. 2013;36(5):e581–7.

    Article  PubMed  Google Scholar 

  100. Morassi LG, Kokkinis K, Evangelopoulos DS, Karargyris O, Vlachou I, Kalokairinou K, et al. Percutaneous radiofrequency ablation of spinal osteoid osteoma under CT-guidance. Br J Radiol. 2014;87:20140003.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  101. Beland M, Mayo-Smith W. Image-guided tumor ablation. In: Kaufman J, Lee M, editors. Vascular and interventional radiology: the requisites. 2nd ed. Philadelphia, PA: Saunders (Elsevier); 2014.

    Google Scholar 

  102. Rybak LD. Fire and ice: thermal ablation of musculoskeletal tumors. Radiol Clin North Am. 2009;47(3):455–69.

    Article  PubMed  Google Scholar 

  103. Callstrom MR, Dupuy DE, Solomon SB, Beres RA, Littrup PJ, Davis KW, et al. Percutaneous image-guided cryoablation of painful metastases involving bone: multicenter trial. Cancer. 2013;119(5):1033–41.

    Article  PubMed  Google Scholar 

  104. McMenomy BP, Kurup AN, Johnson GB, Carter RE, McWilliams RR, Markovic SN, et al. Percutaneous cryoablation of musculoskeletal oligometastatic disease for complete remission. J Vasc Interv Radiol. 2013;24(2):207–13.

    Article  PubMed  Google Scholar 

  105. Callstrom MR, editor. Percutaneous image guided ablation of bone tumors. SIR 39th annual scientific meeting, 2014 March 27, San Diego, CA.

    Google Scholar 

  106. Sabel MS. Cryo-immunology: a review of the literature and proposed mechanisms for stimulatory versus suppressive immune responses. Cryobiology. 2009;58(1):1–11.

    Article  CAS  PubMed  Google Scholar 

  107. Chu KF, Dupuy DE. Thermal ablation of tumours: biological mechanisms and advances in therapy. Nat Rev Cancer. 2014;14:199–208.

    Article  CAS  PubMed  Google Scholar 

  108. Mala T, Samset E, Aurdal L, Gladhaug I, Edwin B, Soreide O. Magnetic resonance imaging-estimated three-dimensional temperature distribution in liver cryolesions: a study of cryolesion characteristics assumed necessary for tumor ablation. Cryobiology. 2001;43(3):268–75.

    Article  CAS  PubMed  Google Scholar 

  109. Mala T. Cryoablation of liver tumours -- a review of mechanisms, techniques and clinical outcome. Minim Invasive Ther Allied Technol. 2006;15(1):9–17.

    Article  PubMed  Google Scholar 

  110. Alblin RJ, Soanes WA, Gonder MJ. Prospects for cryo-immunotherapy in cases of metastasizing carcinoma of the prostate. Cryobiology. 1971;8(3):271–9.

    Article  CAS  PubMed  Google Scholar 

  111. Gursel E, Roberts M, Veenema RJ. Regression of prostatic cancer following sequential cryotherapy to the prostate. J Urol. 1972;108(6):928–32.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Intervention Radiology Section, Department of Radiology, University of Utah, Salt Lake City, UT, USA

    Aaron E. Frodsham MD

  2. 1723 Princeton Ave., Salt Lake City, UT, 84108, USA

    Aaron E. Frodsham MD

  3. Department of Radiology, University of Utah, Salt Lake City, UT, USA

    Laura B. Eisenmenger MD

  4. 974 Stonehenge Dr., North Salt Lake, UT, 84054, USA

    Laura B. Eisenmenger MD

Authors
  1. Aaron E. Frodsham MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Laura B. Eisenmenger MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Aaron E. Frodsham MD .

Editor information

Editors and Affiliations

  1. Huntsman Cancer Institute, The University of Utah, Salt Lake City, Utah, USA

    R. Lor Randall

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer Science+Business Media New York

About this chapter

Cite this chapter

Frodsham, A.E., Eisenmenger, L.B. (2016). Ablation and Cementation Technologies. In: Randall, R. (eds) Metastatic Bone Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5662-9_18

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-5662-9_18

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-5661-2

  • Online ISBN: 978-1-4614-5662-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation